Kasumi-6Homo sapiens (Human)Cancer cell line

Also known as: KASUMI6, KASUMI-6

🤖 AI SummaryBased on 3 publications

Quick Overview

Kasumi-6 is a human leukemia cell line with t(8;21) translocation, used in cancer research.

Detailed Summary

Kasumi-6 is a human leukemia cell line derived from a patient with acute myeloid leukemia (AML-M2) characterized by the t(8;21) chromosomal translocation. This cell line is part of the Kasumi series established in Japan and is widely used in leukemia research due to its well-defined genetic features. The cell line exhibits specific genomic alterations, including mutations in TP53 and the presence of fusion genes such as RUNX1-RUNX1T1, which are critical in the pathogenesis of AML. Kasumi-6 is utilized in studies focusing on drug sensitivity, molecular mechanisms of leukemia, and the development of targeted therapies. Its genomic profile provides insights into the complexity of leukemia and aids in understanding the genetic basis of treatment responses.

Research Applications

Leukemia researchDrug sensitivity studiesMolecular mechanisms of cancerTargeted therapy development

Key Characteristics

t(8;21) translocationTP53 mutationsRUNX1-RUNX1T1 fusion geneGenomic instability
Generated on 6/15/2025

Basic Information

Database IDCVCL_0614
SpeciesHomo sapiens (Human)
Tissue SourcePeripheral blood[UBERON:UBERON_0000178]

Donor Information

Age64
Age CategoryAdult
SexMale
Raceasian

Disease Information

DiseaseAcute myeloid leukemia
LineageMyeloid
SubtypeAcute Myeloid Leukemia
OncoTree CodeAML

DepMap Information

Source TypeATCC
Source IDACH-000166_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Tyr234Asp (c.700T>G)Homozygous-Unknown
MutationUnexplicitFLT3Internal tandem duplication (FLT3-ITD)Unspecified-PubMed=12529668
MutationSimpleCEBPAp.Arg306Pro (c.917G>C)Heterozygous-Unknown, PubMed=12508245

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
10,12
D13S317
8,12
D16S539
9,10
D18S51
16
D19S433
13,15
D21S11
30,30.2
D2S1338
17,22
D3S1358
16,17
D5S818
11
D7S820
9,11
D8S1179
14,15
FGA
24,25
Penta D
11,12
Penta E
5,12
TH01
6,9
TPOX
8,9
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Kasumi leukemia cell lines: characterization of tumor genomes with ethnic origin and scales of genomic alterations.

Kohara A., Kaneko Y., Kawamura M.

Hum. Cell 33:868-876(2020).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPalpha gene.

Kimura A., Inaba T., Koeffler H.P.

Genes Chromosomes Cancer 36:167-174(2003).