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SK-LMS-1Homo sapiens (Human)Cancer cell line

Also known as: SKLMS1, SKLMS-1

🤖 AI SummaryBased on 12 publications

Quick Overview

Human leiomyosarcoma cell line for cancer research.

Detailed Summary

SK-LMS-1 is a human leiomyosarcoma cell line derived from a soft tissue sarcoma. It is commonly used in cancer research to study the molecular mechanisms of sarcoma development and drug response. This cell line has been utilized in studies examining the effects of various anticancer agents and has shown sensitivity to certain therapeutic compounds. Research involving SK-LMS-1 contributes to understanding the genetic and molecular characteristics of leiomyosarcomas, aiding in the development of targeted therapies. The cell line is part of several large-scale cancer cell line databases, providing valuable resources for genomic and pharmacological studies.

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0628
Species	Homo sapiens (Human)
Tissue Source	Vulva[UBERON:UBERON_0000997]

Donor Information

Age	43
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Leiomyosarcoma
Lineage	Soft Tissue
Subtype	Leiomyosarcoma
OncoTree Code	LMS

DepMap Information

Source Type	ATCC
Source ID	ACH-000145_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gly245Ser (c.733G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=28445466
MutationSimple	TP53	p.Met237Lys (c.710T>A)	Unspecified	-	from parent cell line SK-LMS-1

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

9,10

D13S317

11,12

D16S539

8,11

D18S51

14,19

D19S433

14,15

D21S11

28,30

D2S1338

17,24

D3S1358

15,16

D5S818

11,13

D7S820

8,9

D8S1179

12

FGA

22,25

Penta D

12,13

Penta E

7,13

TH01

6,7

TPOX

8,9

vWA

18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Sister chromatid exchange and genomic instability in soft tissue sarcomas: potential implications for response to DNA-damaging treatments.

Salawu A., Wright K., Al-Kathiri A., Wyld L., Reed M.W.R., Sisley K.

Sarcoma 2018:3082526.1-3082526.8(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.

Harris E., Monks A., Morris J.

Mol. Cancer Ther. 14:2452-2462(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Analysis of p53 status in human cell lines using a functional assay in yeast: detection of new non-sense p53 mutation in codon 124.

Smardova J., Pavlova S., Svitakova M., Grochova D., Ravcukova B.

Oncol. Rep. 14:901-907(2005).

Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.

Rousset M., Zweibaum A., Fogh J.

Cancer Res. 41:1165-1170(1981).

Polymorphic enzyme analysis of cultured human tumor cell lines.";

Dracopoli N.C., Fogh J.

J. Natl. Cancer Inst. 70:469-476(1983).

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene.

Fletcher C.D.M., Ball A.B.S., Thomas M., Gusterson B.A., Cooper C.S.

Oncogene 5:1297-1301(1990).

Platelet-derived growth factor (PDGF) receptor activation in cell transformation and human malignancy.

Fleming T.P., Matsui T., Aaronson S.A.

Exp. Gerontol. 27:523-532(1992).

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Fogh J., Wright W.C., Loveless J.D.

J. Natl. Cancer Inst. 58:209-214(1977).

One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

Fogh J., Fogh J.M., Orfeo T.

J. Natl. Cancer Inst. 59:221-226(1977).

New human tumor cell lines.";

Fogh J., Trempe G.L.

(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.115-159; Springer; New York; USA (1975).

Web Resources

thermofisher.com tcpaportal.org