SK-MES-1Homo sapiens (Human)Cancer cell line
Also known as: SKMES, SK-MES, SKMES1, SK-MES1, SK-Mes-1, SKMES-1, SK MES 1
Quick Overview
Human lung cancer cell line with known genetic alterations.
Detailed Summary
Basic Information
| Database ID | CVCL_0630 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 65 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Lung squamous cell carcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Lung Squamous Cell Carcinoma |
| OncoTree Code | LUSC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000665_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Glu298Ter (c.892G>T) | Homozygous | - | from parent cell line SK-MES-1 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Screening human cell lines for viral infections applying RNA-Seq data analysis.
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
PLoS ONE 14:E0210404-E0210404(2019).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.
Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.
Br. J. Cancer 109:1599-1608(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.
Cancer Sci. 101:1891-1896(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
A gene-alteration profile of human lung cancer cell lines.";
Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
Hum. Mutat. 30:1199-1206(2009).
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Zhou X.-M., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.
Cell 131:1190-1203(2007).
High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.
Gazdar A.F., Lam S., MacAulay C., Lam W.L.
Int. J. Cancer 118:1556-1564(2006).
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Hirohashi S., Inazawa J., Imoto I.
Hum. Mol. Genet. 14:997-1007(2005).
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.
Yokoi S., Yasui K., Iizasa T., Imoto I., Fujisawa T., Inazawa J.
Clin. Cancer Res. 9:4705-4713(2003).
RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication.
Mitsudomi T.
Int. J. Cancer 106:45-51(2003).
Persistent increase in chromosome instability in lung cancer: possible indirect involvement of p53 inactivation.
Fujii Y., Takahashi T.
Am. J. Pathol. 159:1345-1352(2001).
Alterations of integrin expression in human lung cancer.";
Takahashi T., Ueda R.
Jpn. J. Cancer Res. 84:168-174(1993).
Secretion of atrial natriuretic peptide and vasopressin by small cell lung cancer.
Lofters W.S., Flynn T.G.
Cancer 75:2442-2451(1995).
HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.
Pollack M.S., Heagney S.D., Livingston P.O., Fogh J.
J. Natl. Cancer Inst. 66:1003-1012(1981).
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
Wright W.C., Daniels W.P., Fogh J.
J. Natl. Cancer Inst. 66:239-247(1981).
Monoclonal antibodies to human squamous cell carcinoma of the lung and their application to tumor diagnosis.
Yamakido M.
Cancer Res. 45:3274-3281(1985).
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.
Cancer Res. 48:589-601(1988).
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Am. J. Pathol. 119:361-366(1985).
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
Fogh J., Wright W.C., Loveless J.D.
J. Natl. Cancer Inst. 58:209-214(1977).
New human tumor cell lines.";
Fogh J., Trempe G.L.
(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.115-159; Springer; New York; USA (1975).