U-118MGHomo sapiens (Human)Cancer cell line
Also known as: U-118 MG, U-118-MG, U118-MG, U118MG, U118, 118 MG, 118MG
Quick Overview
Human glioblastoma cell line with known genetic alterations and tumorigenic potential.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0633 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain[UBERON:UBERON_0000955] |
Donor Information
| Age | 47 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Astrocytoma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Astrocytoma |
| OncoTree Code | ASTR |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000040_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationNone reported | IDH1 | - | - | - | PubMed=19435942 |
| MutationSimple | PTEN | c.1026+1G>T (IVS8+1G>T) | Homozygous | Splice donor mutation | from parent cell line 1181N1 |
| MutationSimple | TP53 | p.Arg213Gln (c.638G>A) | Homozygous | - | from parent cell line 1181N1 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Brain tumors.";
Ali-Osman F.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).
Neoplastic human glia cells in culture.";
Ponten J.
(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.175-206; Springer; New York; USA (1975).
Human glioma cell lines.";
Nister M., Westermark B.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York; USA (1994).
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
Fogh J., Fogh J.M., Orfeo T.
J. Natl. Cancer Inst. 59:221-226(1977).
Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N'-nitro-N-nitrosoguanidine-damaged adenovirus 5.
Day R.S. 3rd, Ziolkowski C.H.J.
Nature 279:797-799(1979).
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
Fogh J., Wright W.C., Loveless J.D.
J. Natl. Cancer Inst. 58:209-214(1977).
Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts.
Friedman H.S., Bigner D.D.
Cancer Res. 50:8017-8022(1990).
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.
Claesson-Welsh L., Heldin C.-H., Schlessinger J., Westermark B.
Cancer Res. 48:3910-3918(1988).
DNA content and chromosomes in permanent cultured cell lines derived from malignant human gliomas.
Bigner S.H., Bjerkvig R., Laerum O.D., Muhlbaier L.H., Bigner D.D.
Anal. Quant. Cytol. Histol. 9:435-444(1987).
The deficient density-dependent growth control of human malignant glioma cells and virus-transformed glia-like cells in culture.
Westermark B.
Int. J. Cancer 12:438-451(1973).
Cytology and growth characteristics of human tumour astrocytes transformed by Rous sarcoma virus.
Macintyre E.H., Grimes R.A., Vatter A.E.
J. Cell Sci. 5:583-602(1969).
Long term culture of normal and neoplastic human glia.";
Ponten J., Macintyre E.H.
Acta Pathol. Microbiol. Scand. 74:465-486(1968).
The ultrastructure of human and murine astrocytes and of human fibroblasts in culture.
Macintyre E.H., Ponten J., Vatter A.E.
Acta Pathol. Microbiol. Scand. A. 80:267-283(1972).
Tumor-specific membrane antigens in established cell lines from gliomas.
Wahlstrom T., Linder E., Saksela E., Westermark B.
Cancer 34:274-279(1974).
Polymorphic enzyme analysis of cultured human tumor cell lines.";
Dracopoli N.C., Fogh J.
J. Natl. Cancer Inst. 70:469-476(1983).
Heterogeneity of genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas.
Ruoslahti E., Herschman H.R., Eng L.F., Wikstrand C.J.
J. Neuropathol. Exp. Neurol. 40:201-229(1981).
HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.
Pollack M.S., Heagney S.D., Livingston P.O., Fogh J.
J. Natl. Cancer Inst. 66:1003-1012(1981).
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Rousset M., Zweibaum A., Fogh J.
Cancer Res. 41:1165-1170(1981).
Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway.
Sharif T.R., Luo W., Sharif M.
Mol. Cell. Endocrinol. 130:119-130(1997).
Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.
Sharif T.R., Sharif M.
Int. J. Oncol. 15:237-243(1999).
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Van Meir E.G.
Brain Pathol. 9:469-479(1999).
Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.
Collins V.P.
J. Neuropathol. Exp. Neurol. 58:1170-1183(1999).
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
Wolf E., Gabius H.-J.
J. Cancer Res. Clin. Oncol. 127:375-386(2001).
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.
Fine H.A.
Cancer Cell 9:391-403(2006).
Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.
Jones C.
PLoS ONE 4:E5209-E5209(2009).
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.
Jones D.T.W., Collins V.P.
Neuro-oncol. 11:341-347(2009).
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Freshney R.I.
Int. J. Cancer 127:1-8(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Hamou M.-F., Delorenzi M., Hegi M.E.
Neuro-oncol. 14:701-711(2012).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Origin of the U87MG glioma cell line: good news and bad news.";
Allen M., Bjerke M., Edlund H., Nelander S., Westermark B.
Sci. Transl. Med. 8:354re3.1-354re3.4(2016).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).