Hs 274.THomo sapiens (Human)Undefined cell line type
Also known as: Hs 274, HS274T, Hs274T, Hs-274-T
🤖 AI SummaryBased on 2 publications
Quick Overview
Human fibroblast cell line for cancer and drug sensitivity research.
Detailed Summary
Hs 274.T is a human fibroblast cell line that has been utilized in cancer research, particularly in studies related to drug sensitivity and anticancer drug profiling. This cell line is part of large-scale genomic and pharmacological studies, contributing to the understanding of how genetic variations influence responses to therapeutic agents. Its role in the Cancer Cell Line Encyclopedia (CCLE) highlights its importance in preclinical models for cancer research. The cell line's fibroblast origin suggests its potential use in studying tumor microenvironment interactions and cellular responses to various treatments. However, specific details about its tissue of origin and disease context remain unknown, limiting its application in certain research areas.
Research Applications
Cancer researchDrug sensitivity profilingAnticancer drug development
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Used in genomic and pharmacological studiesFibroblast origin for tumor microenvironment studies
Generated on 6/15/2025
Basic Information
| Database ID | CVCL_0711 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Breast[UBERON:UBERON_0000310] |
Donor Information
| Age | 66 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Non-Cancerous |
|---|---|
| Lineage | Fibroblast |
| Subtype | Fibroblast, Soft Tissue |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000134_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
11
D16S539
11
D5S818
12,13
D7S820
11
TH01
9,9.3
TPOX
8,10
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Fibroblasts cell lines misclassified as cancer cell lines.";
de Weck A., Bitter H., Kauffmann A.
bioRxiv 2017:166199-166199(2017).