Hs 618.THomo sapiens (Human)Undefined cell line type
Also known as: 618T, HS618T, Hs618T, Hs-618-T
🤖 AI SummaryBased on 3 publications
Quick Overview
Human lung fibroblast cell line for cancer research
Detailed Summary
The Hs 618.T cell line is a human lung fibroblast cell line derived from lung tissue. It is commonly used in cancer research due to its fibroblast characteristics, which are relevant for studying tumor microenvironments and cancer progression. This cell line provides a valuable model for investigating molecular mechanisms and drug responses in lung-related malignancies. Its utility extends to studies involving cell signaling, gene expression, and therapeutic target identification. The cell line's origin as a fibroblast makes it particularly useful for understanding interactions between cancer cells and the surrounding stromal cells in the lung.
Research Applications
Cancer researchTumor microenvironment studiesDrug response analysisGene expression profilingCell signaling investigations
Key Characteristics
Human originLung fibroblastRelevance to cancer studies
Generated on 6/15/2025
Basic Information
| Database ID | CVCL_0827 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 60 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Non-Cancerous |
|---|---|
| Lineage | Fibroblast |
| Subtype | Fibroblast, Soft Tissue |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000539_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
12,13
D16S539
11,12
D5S818
9,10
D7S820
12,14
TH01
7,10
TPOX
8,11
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Monoclonal antibodies against two human lung carcinoma cell lines.";
Brown D.T., Moore M.
Br. J. Cancer 46:794-801(1982).
Fibroblasts cell lines misclassified as cancer cell lines.";
de Weck A., Bitter H., Kauffmann A.
bioRxiv 2017:166199-166199(2017).