Hs 675.THomo sapiens (Human)Undefined cell line type

Also known as: 675T, Hs675, HS675T, Hs675T, Hs-675-T

🤖 AI SummaryBased on 7 publications

Quick Overview

Human fibroblast cell line for cancer research and drug sensitivity studies.

Detailed Summary

Hs 675.T is a human fibroblast cell line derived from cancerous tissue. It is used in research to study cancer biology, drug sensitivity, and genetic mutations. This cell line has been characterized in multiple studies for its response to various treatments and its genomic features. It is part of large panels like the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its potential in predicting therapeutic responses. The cell line's properties make it a valuable tool for understanding cancer mechanisms and developing targeted therapies.

Research Applications

Cancer researchDrug sensitivity studiesGenomic analysisTherapeutic response prediction

Key Characteristics

Used in large-scale cancer cell line panelsCharacterized for drug response and genetic mutationsPart of the Cancer Cell Line Encyclopedia (CCLE)

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0836
Species	Homo sapiens (Human)
Tissue Source	Colon[UBERON:UBERON_0001155]

Donor Information

Age Category	Unknown
Sex	Male
Race	caucasian

Disease Information

Disease	Non-Cancerous
Lineage	Fibroblast
Subtype	Fibroblast, Soft Tissue

DepMap Information

Source Type	ATCC
Source ID	ACH-000214_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

10,14

D16S539

D18S51

12,16

D19S433

16,16.2

D21S11

29,32.2

D2S1338

24,25

D3S1358

D5S818

10,12

D7S820

9,10

D8S1179

FGA

20,26

Penta D

9,10

Penta E

5,11

TH01

7,9.3

TPOX

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Human tumor cell strains defective in the repair of alkylation damage.

Mattern M.R.

Carcinogenesis 1:21-32(1980).

DOI PubMed

Nuclear ultrastructure of epithelial cell lines derived from human carcinomas and nonmalignant tissues.

Smith H.S., Springer E.L., Hackett A.J.

Cancer Res. 39:332-344(1979).

PubMed

In vitro properties of epithelial cell lines established from human carcinomas and nonmalignant tissue.

Smith H.S.

J. Natl. Cancer Inst. 62:225-230(1979).

DOI PubMed

Epithelial cell cultures from normal and cancerous human tissues.";

Owens R.B., Smith H.S., Nelson-Rees W.A., Springer E.L.

J. Natl. Cancer Inst. 56:843-849(1976).

DOI PubMed

Fibroblasts cell lines misclassified as cancer cell lines.";

de Weck A., Bitter H., Kauffmann A.

bioRxiv 2017:166199-166199(2017).

DOI