Hs 695THomo sapiens (Human)Cancer cell line

Also known as: Hs695, HS695T, Hs695T, HS 695T, HS-695T, Hs-695-T, Hs 695.T, Hs 69ST

🤖 AI SummaryBased on 8 publications

Quick Overview

Human melanoma cell line for cancer research

Detailed Summary

Hs 695T is a human melanoma cell line derived from a metastatic tumor. It exhibits characteristics of malignant transformation including abnormal morphology, high growth rate, and tumorigenicity in immunosuppressed mice. The cell line shows variability in pigmentation and expresses melanin, though to a lesser extent compared to some other melanoma lines. It has been used in studies related to tumor biology, drug sensitivity, and genetic analysis. Hs 695T demonstrates the ability to form colonies in semisolid media and shows specific karyotypic features, indicating its potential for research in cancer genetics and therapeutic development.

Research Applications

Cancer biologyDrug sensitivityGenetic analysisTumor formationCell line characterization

Key Characteristics

Metastatic originAbnormal morphologyHigh growth rateTumorigenic in miceVariable pigmentation

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0851
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	26
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Amelanotic melanoma
Lineage	Skin
Subtype	Melanoma
OncoTree Code	MEL

DepMap Information

Source Type	ATCC
Source ID	ACH-000799_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TERT	c.1-146C>T (c.250C>T) (C250T)	Unspecified	In promoter	PubMed=31068700
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

9,13

D18S51

D19S433

14,15

D21S11

D2S1338

D3S1358

D5S818

D7S820

9,10

D8S1179

13,15

FGA

21,24

Penta D

9,12

Penta E

5,11

TH01

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Human tumor cell strains defective in the repair of alkylation damage.

Mattern M.R.

Carcinogenesis 1:21-32(1980).

DOI PubMed

A molecular approach to the identification and individualization of human and animal cells in culture: isozyme and allozyme genetic signatures.

O'Brien S.J., Shannon J.E., Gail M.H.

In Vitro 16:119-135(1980).

DOI PubMed

Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.

Gershwin M.E., Lentz D., Owens R.B.

Exp. Cell Biol. 52:361-370(1984).

DOI PubMed

Biological properties of human melanoma cells in culture.";

Madin S.H.

In Vitro 15:342-350(1979).

DOI PubMed