Hs 706.THomo sapiens (Human)Cancer cell line
Also known as: HS706T, Hs706T, Hs-706-T
🤖 AI SummaryBased on 3 publications
Quick Overview
Human sarcoma cell line for cancer research.
Detailed Summary
Hs 706.T is a human sarcoma cell line used in cancer research. It is part of a panel of sarcoma cell lines screened for drug responses and molecular characteristics. The cell line has been utilized in studies involving oncology drugs and investigational agents, with data on gene expression and microRNA profiles available. Research has identified patterns of drug sensitivity and resistance, contributing to the understanding of sarcoma biology and potential therapeutic targets. The cell line's response to various compounds has been analyzed in the context of molecular profiling, providing insights into potential treatment strategies.
Research Applications
Drug screeningMolecular profilingCancer research
Key Characteristics
Sarcoma cell lineGene expression data availableMicroRNA expression data available
Generated on 6/15/2025
Basic Information
| Database ID | CVCL_0863 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone[UBERON:UBERON_0002481] |
Donor Information
| Age | 16 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Giant cell tumor of bone |
|---|---|
| Lineage | Fibroblast |
| Subtype | Fibroblast, Soft Tissue |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000071_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TERT | c.1-146C>T (c.250C>T) (C250T) | Unspecified | In promoter | PubMed=31068700 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12,13
D13S317
8,13
D16S539
13
D18S51
12,13
D19S433
13,15
D21S11
31.2,32.2
D2S1338
17,22
D3S1358
16,17
D5S818
11,12
D7S820
9,10
D8S1179
12,15
FGA
21,24
Penta D
11,12
Penta E
11,12
TH01
8,9
TPOX
8,10
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Harris E., Monks A., Morris J.
Mol. Cancer Ther. 14:2452-2462(2015).