Hs 821.THomo sapiens (Human)Undefined cell line type

Also known as: HS821T, Hs821T, Hs-821-T

🤖 AI SummaryBased on 2 publications

Quick Overview

Human fibroblast cell line for cancer and drug sensitivity research.

Detailed Summary

Hs 821.T is a human fibroblast cell line that has been utilized in cancer research, particularly in studies related to drug sensitivity and anticancer drug profiling. This cell line is part of the Cancer Cell Line Encyclopedia (CCLE), which provides comprehensive genomic and pharmacological data for a wide range of cancer cell lines. The CCLE includes detailed information on gene expression, chromosomal copy number, and massively parallel sequencing data, enabling researchers to identify predictors of drug sensitivity. Hs 821.T's inclusion in this extensive dataset allows for the exploration of genetic and molecular factors that influence responses to various anticancer therapies. The cell line's role in these studies contributes to the development of personalized treatment strategies and the understanding of cancer biology.

Research Applications

Cancer researchDrug sensitivity profilingAnticancer drug profiling

Key Characteristics

Part of the Cancer Cell Line Encyclopedia (CCLE)Used for genomic and pharmacological data analysis
Generated on 6/15/2025

Basic Information

Database IDCVCL_0932
SpeciesHomo sapiens (Human)
Tissue SourceBone[UBERON:UBERON_0002481]

Donor Information

Age31
Age CategoryAdult
SexFemale
Racecaucasian

Disease Information

DiseaseNon-Cancerous
LineageFibroblast
SubtypeFibroblast, Soft Tissue

DepMap Information

Source TypeATCC
Source IDACH-000526_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
12,13
D13S317
9,11
D16S539
10,12
D18S51
16,18
D19S433
13,15
D21S11
29,31.2
D2S1338
20,23
D3S1358
16,18
D5S818
12,13
D7S820
10,12
D8S1179
13,14
FGA
24,27
Penta D
12,14
Penta E
11,14
TH01
7,9.3
TPOX
8,11
vWA
14,15
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Fibroblasts cell lines misclassified as cancer cell lines.";

de Weck A., Bitter H., Kauffmann A.

bioRxiv 2017:166199-166199(2017).