Hs 834.THomo sapiens (Human)Undefined cell line type

The Hs 834.T cell line is a human fibroblast cell line that has been studied in cancer research. It was identified in a genome-wide screen for microdeletions that revealed disruption of polarity complex genes in various human cancers. Specifically, the cell line was found to have homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. This cell line is part of a study that demonstrated the importance of PARD3 in maintaining cell polarity and its potential role as a tumor suppressor. The research showed that reconstituting PARD3 expression in cells with deletions could restore tight junctions and affect cell proliferation. These findings highlight the cell line's value in understanding the genetic mechanisms underlying cancer development and progression.