Hs 839.THomo sapiens (Human)Undefined cell line type
Also known as: HS839T, Hs839T, Hs839.T, Hs-839-T
🤖 AI SummaryBased on 5 publications
Quick Overview
Human skin fibroblast cell line for cancer research.
Detailed Summary
Hs 839.T is a human skin fibroblast cell line used in cancer research. It is part of a comprehensive collection of cancer cell lines that have been analyzed for their genomic and transcriptomic profiles. These cell lines are valuable for studying the molecular mechanisms of cancer and for developing targeted therapies. The cell line is characterized by its origin from skin fibroblasts and is used in various research applications including drug sensitivity testing and genetic studies.
Generated on 6/15/2025
Basic Information
| Database ID | CVCL_0941 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Skin[UBERON:UBERON_0002097] |
Donor Information
| Age | 42 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Non-Cancerous |
|---|---|
| Lineage | Fibroblast |
| Subtype | Fibroblast, Soft Tissue |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000180_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Pro278Ser (c.832C>T) | Unspecified | - | PubMed=24662767, PubMed=21602893 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,12
D13S317
11,13
D16S539
11,12
D18S51
16,17
D19S433
14
D21S11
29
D2S1338
19,20
D3S1358
14,17
D5S818
11,12
D7S820
10,12
D8S1179
12,16
FGA
20,23
Penta D
12,13
Penta E
12,15
TH01
7
TPOX
8,11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Fibroblasts cell lines misclassified as cancer cell lines.";
de Weck A., Bitter H., Kauffmann A.
bioRxiv 2017:166199-166199(2017).