Hs 852.THomo sapiens (Human)Cancer cell line
Also known as: Hs852, HS852T, Hs852T, Hs852.T, HS852.T, Hs-852-T
🤖 AI SummaryBased on 7 publications
Quick Overview
Human melanoma cell line derived from a primary tumor, used in cancer research.
Detailed Summary
Hs 852.T is a human melanoma cell line derived from a primary tumor, specifically a melanotic melanoma located in the supraperiosteal region under a fingernail. This cell line is characterized as an epithelial cell type, though its tissue origin is noted as 'Unknown'. The cell line has been used in studies related to melanoma biology, including investigations into its growth properties, morphology, and tumorigenic potential. Research has shown that Hs 852.T exhibits certain malignant characteristics, such as the ability to form colonies in semisolid media and to grow in contact-inhibited monolayers of normal fibroblasts and epithelial cells. However, it shows lower tumorigenicity in immunosuppressed mice compared to other melanoma cell lines. The cell line has been maintained in culture for multiple passages and is available for further research into melanoma progression and therapeutic strategies.
Research Applications
Cancer researchMelanoma biologyTumorigenicity studiesCell culture and characterization
Key Characteristics
Primary melanoma originEpithelial cell typeTumorigenic in immunosuppressed miceColony formation in semisolid mediaGrowth in contact-inhibited monolayers
Generated on 6/15/2025
Basic Information
| Database ID | CVCL_0950 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Skin[UBERON:UBERON_0002097] |
Donor Information
| Age | 53 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000274_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | NRAS | p.Gly12Val (c.35G>T) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
13
D13S317
9,12
D16S539
9,11
D18S51
13.3,15.3
D19S433
13,15.2
D21S11
30
D2S1338
19
D3S1358
15,16
D5S818
12
D7S820
10,11
D8S1179
14,16
FGA
18,21
Penta D
11,13
Penta E
11,16
TH01
9
TPOX
8,10
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Human tumor cell strains defective in the repair of alkylation damage.
Mattern M.R.
Carcinogenesis 1:21-32(1980).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).