CHLA-218Homo sapiens (Human)Cancer cell line
Also known as: CHLA218
🤖 AI SummaryBased on 1 publications
Quick Overview
Human cell line with STAG2 mutations linked to Ewing sarcoma.
Detailed Summary
CHLA-218 is a human cell line associated with Ewing sarcoma, characterized by mutations in the STAG2 gene. These mutations are frequently observed in Ewing sarcoma family of tumors (EFT) and are linked to altered molecular profiles. The cell line is part of a study that identified recurrent STAG2 mutations in EFT, highlighting its relevance in understanding the genetic basis of this cancer. Research on CHLA-218 contributes to the exploration of molecular mechanisms and potential therapeutic targets in Ewing sarcoma.
Research Applications
Ewing sarcoma researchSTAG2 mutation analysisGenomic profiling of tumors
Key Characteristics
STAG2 mutationsEwing sarcoma association
Generated on 6/15/2025
Basic Information
| Database ID | CVCL_0B48 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
Disease Information
| Disease | Primitive neuroectodermal tumor |
|---|---|
| Lineage | Bone |
| Subtype | Ewing Sarcoma |
| OncoTree Code | ES |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001030_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
8,11
D16S539
12
D18S51
11,13
D19S433
13,16
D21S11
29,31
D2S1338
23
D3S1358
16
D5S818
11,12
D7S820
10
D8S1179
8,13
FGA
21,24
TH01
7
TPOX
8,11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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