CIIHomo sapiens (Human)Transformed cell line

The CII cell line is a human lymphoid cell line established from a patient with chronic lymphocytic leukemia (CLL). It was derived by infecting blood cells with Epstein-Barr virus (EBV), leading to the transformation of leukemic cells into a continuously growing cell line. The CII line exhibits characteristics of B-lymphoid cells, including the expression of IgM and lambda light chains, which are consistent with the monoclonal immunoglobulin found in the patient's leukemic cells. Chromosomal abnormalities were observed in the CII line, including trisomy 12 and other structural rearrangements, suggesting a leukemic origin. The cell line has been used to study the differentiation of B-lymphoid cells and the role of EBV in transforming leukemic cells. Research on CII has contributed to understanding the genetic and immunological features of CLL and has been utilized in studies involving cell lineage and chromosomal analysis.