Hs 939.THomo sapiens (Human)Cancer cell line
Also known as: HS939T, Hs939T, Hs939-T, HS-939-T, Hs-939-T
🤖 AI SummaryBased on 3 publications
Quick Overview
Human cell line for cancer research
Detailed Summary
Hs 939.T is a human cell line used in cancer research. It is derived from a tumor and is utilized for studying various aspects of cancer biology, including genetic mutations and drug sensitivity. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in studies related to drug response and genetic profiling. Research on this cell line has contributed to understanding the molecular mechanisms of cancer and the development of targeted therapies.
Research Applications
Cancer researchDrug sensitivity studiesGenetic profiling
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Used in studies of drug response and genetic mutations
Generated on 6/16/2025
Basic Information
| Database ID | CVCL_1036 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 24 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000814_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | CDKN2A | p.Arg58Ter (c.172C>T) (p.Pro72Leu, c.215C>T) | Unspecified | - | PubMed=9598804 |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
8,11
D16S539
9,11
D5S818
11,12
D7S820
8,11
TH01
7,9.3
TPOX
8
vWA
14,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Nat. Commun. 10:3574.1-3574.11(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).