Hs 940.THomo sapiens (Human)Undefined cell line type

Also known as: HS940, Hs-940, HS940T, Hs940T, Hs940.T, Hs940-T, HS-940-T, Hs-940-T

🤖 AI SummaryBased on 5 publications

Quick Overview

Human skin fibroblast cell line for cancer research.

Detailed Summary

Hs 940.T is a human skin fibroblast cell line used in cancer research. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for genetic and molecular characteristics. The cell line is utilized in studies related to oncogenic fusions, gene expression, and drug sensitivity. Research has identified various mutations and fusion genes in this cell line, contributing to understanding cancer biology and therapeutic responses. The cell line's genetic profile includes mutations in BRAF and PTEN, which are relevant to melanoma and other cancers. It is also used to study the effects of targeted therapies and to identify biomarkers for drug response.

Research Applications

Oncogenic fusionsGene expression analysisDrug sensitivity testingMutation profiling

Key Characteristics

BRAF mutationPTEN mutationOncogenic fusionsGene expression patterns

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1038
Species	Homo sapiens (Human)
Tissue Source	Skin[UBERON:UBERON_0002097]

Donor Information

Age	57
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Non-Cancerous
Lineage	Fibroblast
Subtype	Fibroblast, Soft Tissue

DepMap Information

Source Type	ATCC
Source ID	ACH-000135_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Val216Leu (c.646G>T)	Homozygous	-	Unknown, Unknown
MutationSimple	NRAS	p.Gln61Arg (c.182A>G)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

11,12

D16S539

9,12

D18S51

13,14

D19S433

13,14

D21S11

D2S1338

D3S1358

15,18

D5S818

D7S820

D8S1179

12,13

FGA

22,23

Penta D

Penta E

7,12

TH01

9,9.3

TPOX

8,11

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.

Tsao H., Goel V., Wu H., Yang G., Haluska F.G.

J. Invest. Dermatol. 122:337-341(2004).

DOI PubMed PMC

Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.

Tsao H., Zhang X., Fowlkes K., Haluska F.G.

Cancer Res. 60:1800-1804(2000).

PubMed

Fibroblasts cell lines misclassified as cancer cell lines.";

de Weck A., Bitter H., Kauffmann A.

bioRxiv 2017:166199-166199(2017).

DOI