23132/87Homo sapiens (Human)Cancer cell line

Also known as: 23132, St23132, St 23132, 2313287, 23132-87

🤖 AI SummaryBased on 10 publications

Quick Overview

Human gastric cancer cell line with ZAK isoform upregulation and potential for drug sensitivity studies.

Detailed Summary

The 23132/87 cell line is a human gastric cancer cell line derived from a primary tumor. It exhibits upregulation of the ZAK kinase isoform TV1, which has been implicated in cancer progression and is a potential target for therapeutic intervention. This cell line is valuable for studying the role of ZAK isoforms in gastric cancer and for evaluating drug sensitivity in preclinical models. The cell line has been used in studies to identify genetic and transcriptomic alterations associated with gastric cancer, including mutations in key oncogenes and tumor suppressor genes. Research on this cell line contributes to understanding the molecular mechanisms underlying gastric cancer and the development of targeted therapies.

Research Applications

Study of ZAK isoform function in gastric cancerDrug sensitivity profilingGenomic and transcriptomic analysis of gastric cancerInvestigation of oncogenic mutations and tumor suppressor gene alterations

Key Characteristics

Upregulation of ZAK TV1 isoformPotential for targeted therapy researchUsed in identification of cancer-related mutations

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1046
Species	Homo sapiens (Human)
Tissue Source	Stomach[UBERON:UBERON_0000945]

Donor Information

Age	72
Age Category	Adult
Sex	Male

Disease Information

Disease	Gastric adenocarcinoma
Lineage	Esophagus/Stomach
Subtype	Stomach Adenocarcinoma
OncoTree Code	STAD

DepMap Information

Source Type	DSMZ
Source ID	ACH-000948_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

8,9,10

D13S317

11,12

D16S539

11,13,14

D18S51

12,13

D19S433

12,13

D21S11

28,31.2

D2S1338

17,19,20

D3S1358

15,16

D5S818

10,11

D7S820

9.3,12

D8S1179

11,12,13,15

FGA

20,21,22

Penta D

9,12

Penta E

6,16

TH01

9,9.3

TPOX

10,11

vWA

15,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

DOI PubMed

Characterization of four new gastric cancer cell lines.";

Betz C., Saal K., Muller-Hermelink H.-K.

Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol. 63:335-343(1993).

DOI PubMed