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647VHomo sapiens (Human)Cancer cell line

Also known as: 647 V, 647-V, 647B

🤖 AI SummaryBased on 12 publications

Quick Overview

Human bladder cancer cell line with known genetic alterations.

Detailed Summary

The 647V cell line is a human bladder cancer cell line derived from a transitional cell carcinoma. It is characterized by specific genetic alterations, including homozygous deletions in the 9p21 region, which affects genes such as CDKN2, CDKN2B, and MTAP. These deletions are associated with the loss of tumor suppressor functions, contributing to cancer progression. The cell line is used in research to study the molecular mechanisms of bladder cancer and to evaluate therapeutic strategies targeting these genetic alterations. Additionally, it has been involved in studies related to the TSC1 gene, although specific details about its mutations are not fully detailed in the provided data.

Research Applications

Genetic alteration studiesTumor suppressor gene analysisTherapeutic target identification

Key Characteristics

Homozygous deletions in 9p21 regionLoss of CDKN2, CDKN2B, and MTAP genesUsed in bladder cancer research
Generated on 6/16/2025

Basic Information

Database IDCVCL_1049
SpeciesHomo sapiens (Human)
Tissue SourceUrinary bladder[UBERON:UBERON_0001255]

Donor Information

Age59
Age CategoryAdult
SexMale

Disease Information

DiseaseBladder carcinoma
LineageBladder/Urinary Tract
SubtypeBladder Urothelial Carcinoma
OncoTree CodeBLCA

DepMap Information

Source TypeDSMZ
Source IDACH-000896_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Glu336Ter (c.1006G>T)Homozygous-from parent cell line SN12C-PM6
MutationSimpleTP53p.Ile162Asn (c.485T>A)Heterozygous-from parent cell line 647V
MutationSimpleTERTc.1-124C>T (c.228C>T) (C228T)UnspecifiedIn promoterfrom parent cell line Hep-G2
MutationSimpleMDM4p.Ser161Ter (c.482C>G)Heterozygous-from parent cell line 647V
MutationSimpleEP300p.Gln993Ter (c.2977C>T)Homozygous-from parent cell line 647V

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
12
D13S317
11,14
D16S539
11
D18S51
13
D19S433
12
D21S11
28,30
D2S1338
24
D3S1358
16
D5S818
11
D7S820
8,11
D8S1179
12,13
FGA
20,22
Penta D
10,11
Penta E
13
TH01
7
TPOX
8
vWA
18,21
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOIPubMedPMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOIPubMedPMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOIPubMedPMC

Systematic review: characteristics and preclinical uses of bladder cancer cell lines.

Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.

Bladder Cancer 4:169-183(2018).

DOIPubMedPMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOIPubMedPMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOIPubMedPMC

Identification of mutations in distinct regions of p85 alpha in urothelial cancer.

Knowles M.A.

PLoS ONE 8:E84411-E84411(2013).

DOIPubMedPMC

Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.

Hurst C.D., Platt F.M., Knowles M.A.

Eur. Urol. 65:367-369(2014).

DOIPubMed

TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.

Kwiatkowski D.J.

J. Pathol. 230:17-27(2013).

DOIPubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOIPubMedPMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOIPubMedPMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOIPubMedPMC

Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro.

Knowles M.A.

Genes Chromosomes Cancer 43:315-328(2005).

DOIPubMed

The 9p21 region in bladder cancer cell lines: large homozygous deletion inactivate the CDKN2, CDKN2B and MTAP genes.

Stadler W.M., Olopade O.I.

Urol. Res. 24:239-244(1996).

DOIPubMed

Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.

Rousset M., Zweibaum A., Fogh J.

Cancer Res. 41:1165-1170(1981).

PubMed

Human urologic cancer cell lines.";

Williams R.D.

Invest. Urol. 17:359-363(1980).

PubMed

Polymorphic enzyme analysis of cultured human tumor cell lines.";

Dracopoli N.C., Fogh J.

J. Natl. Cancer Inst. 70:469-476(1983).

PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOIPubMed

In vitro cultivation of epithelial cells derived from tumors of the human urinary tract.

Elliott A.Y., Bronson D.L., Stein N., Fraley E.E.

Cancer Res. 36:365-369(1976).

PubMed

Transitional cell cancer: establishment and characterization of cell lines.

Elliott A.Y., Bronson D.L., Fraley E.E.

Natl. Cancer Inst. Monogr. 49:23-24(1978).

PubMed

Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors.

Fogh J.

Natl. Cancer Inst. Monogr. 49:5-9(1978).

PubMed

Properties of cell lines established from transitional cell cancers of the human urinary tract.

Elliott A.Y., Bronson D.L., Cervenka J., Stein N., Fraley E.E.

Cancer Res. 37:1279-1289(1977).

PubMed

Establishment and characterization of epithelial cell cultures from tumors of the human urinary tract.

Elliott A.Y., Bronson D.L., Cervenka J., Cleveland P.H., Fraley E.E.

(In book chapter) Cell culture and the application; Acton R. (eds.); pp.711-728; Academic Press; New York; USA (1977).

DOI