769-PHomo sapiens (Human)Cancer cell line
Also known as: 769-p, 769P
Quick Overview
Renal cell carcinoma cell line with clear cell morphology and genetic alterations.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1050 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Kidney[UBERON:UBERON_0002113] |
Donor Information
| Age | 63 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Renal cell carcinoma |
|---|---|
| Lineage | Kidney |
| Subtype | Renal Clear Cell Carcinoma |
| OncoTree Code | CCRCC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000411_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Hsieh J.J.-D., Hakimi A.A.
Nat. Commun. 8:15165.1-15165.10(2017).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Choosing the right cell line for renal cell cancer research.";
Czarnecka A.M.
Mol. Cancer 15:83.1-83.15(2016).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.
Int. J. Cancer 132:E11-E17(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma.
Mimata H., Seto M., Moriyama M.
BMC Cancer 11:523.1-523.10(2011).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
High resolution array-CGH analysis of single cells.";
Carter N.P., Speicher M.R.
Nucleic Acids Res. 35:e15.1-e15.10(2007).
In vitro cultivation of human renal cell cancer. I. Establishment of cells in culture.
Williams R.D., Elliott A.Y., Stein N., Fraley E.E.
In Vitro 12:623-627(1976).