8-MG-BAHomo sapiens (Human)Cancer cell line

Also known as: 8MGBA

🤖 AI SummaryBased on 5 publications

Quick Overview

Human glioma cell line with potential for cancer research.

Detailed Summary

The 8-MG-BA cell line is a human glioma-derived cell line that has been characterized for its intermediate filament expression. It is part of the DSMZ cell line collection and is used in cancer research. This cell line is known to express vimentin and keratin, indicating its mesenchymal and epithelial characteristics. It has been used in studies related to tumor biology and drug sensitivity. The cell line's origin is from a glioma, and it is utilized in various research applications including drug screening and molecular studies. The 8-MG-BA cell line is one of the many cell lines available for studying gliomas and other cancers.

Research Applications

Cancer researchDrug screeningMolecular studies

Key Characteristics

Vimentin expressionKeratin expressionGlioma origin

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1052
Species	Homo sapiens (Human)
Tissue Source	Brain, frontal lobe[UBERON:UBERON_0016525]

Donor Information

Age	54
Age Category	Adult
Sex	Female
Race	black_or_african_american

Disease Information

Disease	Glioblastoma
Lineage	CNS/Brain
Subtype	Glioblastoma
OncoTree Code	GB

DepMap Information

Source Type	DSMZ
Source ID	ACH-000137_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273Cys (c.817C>T)	Homozygous	-	PubMed=35933914

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11

D13S317

D16S539

D18S51

D19S433

12,14

D21S11

28,29

D2S1338

16,17

D3S1358

D5S818

10,12

D7S820

D8S1179

FGA

21,24

Penta D

12,14

Penta E

12,16

TH01

9,9.3

TPOX

8,10

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

DOI PubMed

Characterization of two new permanent glioma cell lines 8-MG-BA and 42-MG-BA.

Perzelova A., Macikova I., Mraz P., Bizik I., Steno J.

Neoplasma 45:25-29(1998).

PubMed