A101DHomo sapiens (Human)Cancer cell line
Also known as: A-101D
Quick Overview
Human melanoma cell line with potential for cancer research.
Detailed Summary
Basic Information
| Database ID | CVCL_1057 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age | 56 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000008_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Human tumor cell strains defective in the repair of alkylation damage.
Mattern M.R.
Carcinogenesis 1:21-32(1980).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Mutations of the BRAF gene in human cancer.";
Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Nature 417:949-954(2002).
A molecular approach to the identification and individualization of human and animal cells in culture: isozyme and allozyme genetic signatures.
O'Brien S.J., Shannon J.E., Gail M.H.
In Vitro 16:119-135(1980).
Differential expression of the amv gene in human hematopoietic cells.
Aaronson S.A., Wong-Staal F.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).
Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.
Yarosh D.B., Foote R.S., Mitra S., Day R.S. 3rd
Carcinogenesis 4:199-205(1983).