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A-253Homo sapiens (Human)Cancer cell line

Also known as: A253, A 253

🤖 AI SummaryBased on 13 publications

Quick Overview

Human salivary gland carcinoma cell line for cancer research.

Detailed Summary

The A-253 cell line is a human salivary gland carcinoma cell line derived from a submandibular gland tumor. It is widely used in cancer research for studying tumor biology, drug sensitivity, and genetic characteristics. The cell line has been characterized for its growth properties and is part of various cancer cell line databases. Research on A-253 has contributed to understanding the molecular mechanisms of salivary gland cancers and their response to therapeutic interventions.

Research Applications

Cancer researchDrug sensitivity studiesGenetic and molecular analysis

Key Characteristics

Epithelial originUsed in tumor biology studiesPart of cancer cell line databases

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1060
Species	Homo sapiens (Human)
Tissue Source	Salivary gland, submandibular gland[UBERON:UBERON_0001736]

Donor Information

Age	54
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Squamous cell carcinoma of salivary glands
Lineage	Head and Neck
Subtype	Oral Cavity Squamous Cell Carcinoma
OncoTree Code	OCSC

DepMap Information

Source Type	ATCC
Source ID	ACH-000740_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Glu180fs*67 (c.539delA)	Homozygous	-	from parent cell line A-253
MutationSimple	PTEN	p.Leu152Pro (c.455T>C)	Homozygous	-	from parent cell line A-253
MutationSimple	KMT2D	p.Gly3092Ter (c.9274G>T)	Heterozygous	-	from parent cell line A-253
MutationSimple	CDKN2A	p.Ala17fs*5 (c.49_61delGCCACGGCCGCGG)	Heterozygous	-	from parent cell line A-253

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

12,13

D13S317

9,12

D16S539

12

D18S51

13

D19S433

13

D21S11

30,30.2

D2S1338

25,26

D3S1358

15

D5S818

11

D7S820

10,12

D8S1179

13

FGA

25

Penta D

13

Penta E

7

TH01

6,8

TPOX

8,12

vWA

16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Cross-contamination of the human salivary gland HSG cell line with HeLa cells: a STR analysis study.

Perret J., Chiorini J.A., Delporte C., Tran S.D.

Oral Dis. 24:1477-1483(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Human tumor cell strains defective in the repair of alkylation damage.

Mattern M.R.

Carcinogenesis 1:21-32(1980).

Integrative molecular characterization of head and neck cancer cell model genomes.

Tsui I.F.L., Garnis C.

Head Neck 32:1143-1160(2010).

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.

Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D.

Nature 288:724-727(1980).

In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.

Dosik H., Parks W.P.

J. Natl. Cancer Inst. 51:1417-1423(1973).

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

Multiparametric flow cytometry of human squamous cell carcinoma lines from the head and neck.

Wustrow T.P.U., Raffael A., Valet G.K.

Otolaryngol. Head Neck Surg. 98:552-557(1988).

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Fogh J., Wright W.C., Loveless J.D.

J. Natl. Cancer Inst. 58:209-214(1977).

One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

Fogh J., Fogh J.M., Orfeo T.

J. Natl. Cancer Inst. 59:221-226(1977).

Head and neck tumor cell lines.";

Carey T.E.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).