Back to Cell Types

A-388Homo sapiens (Human)Cancer cell line

Also known as: A388

🤖 AI SummaryBased on 10 publications

Quick Overview

Human tumor cell line derived from epidermoid carcinoma, used in cancer research.

Detailed Summary

A-388 is a human tumor cell line derived from epidermoid carcinoma, commonly used in cancer research. It exhibits characteristics of malignant cells, including uncontrolled growth and the ability to form tumors in vivo. The cell line is utilized in studies related to tumor biology, drug screening, and understanding the mechanisms of cancer progression. Research on A-388 has contributed to the identification of genetic and molecular alterations associated with cancer development and treatment resistance. Its use in in vitro and in vivo models provides insights into tumor behavior and potential therapeutic targets.

Research Applications

Cancer researchDrug screeningTumor biology studiesGenetic and molecular analysis

Key Characteristics

Malignant cell growthTumor formation in vivoResistance to certain chemotherapeutic agents

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1063
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	86
Age Category	Adult
Sex	Male

Disease Information

Disease	Skin squamous cell carcinoma
Lineage	Skin
Subtype	Cutaneous Squamous Cell Carcinoma
OncoTree Code	CSCC

DepMap Information

Source Type	ATCC
Source ID	ACH-001442_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys135Phe (c.404G>T)	Heterozygous	-	PubMed=22170099, PubMed=19147553, PubMed=16142320
MutationSimple	PIK3CA	p.Glu545Lys (c.1633G>A)	Heterozygous	-	from parent cell line MCF-7
MutationSimple	EGFR	p.Arg832Cys (c.2494C>T)	Heterozygous	-	from parent cell line A388.6TG.c2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,11

D13S317

11

D16S539

11,12

D18S51

14

D19S433

12,15

D21S11

28,30

D2S1338

18,25

D3S1358

13

D5S818

11,13

D7S820

10

D8S1179

12,13

FGA

22

Penta D

7,10

Penta E

11,13

TH01

9,9.3

TPOX

8,9

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Human tumor cell strains defective in the repair of alkylation damage.

Mattern M.R.

Carcinogenesis 1:21-32(1980).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Differential expression of the amv gene in human hematopoietic cells.

Aaronson S.A., Wong-Staal F.

Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.

Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D.

Nature 288:724-727(1980).

In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.

Dosik H., Parks W.P.

J. Natl. Cancer Inst. 51:1417-1423(1973).

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

Tumorigenic suppression of a human cutaneous squamous cell carcinoma cell line in the nude mouse skin graft assay.

Conway K., Morgan D., Phillips K.K., Yuspa S.H., Weissman B.E.

Cancer Res. 52:6487-6495(1992).

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Fogh J., Wright W.C., Loveless J.D.

J. Natl. Cancer Inst. 58:209-214(1977).

Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces.

Sherwin S.A., Sliski A.H., Todaro G.J.

Proc. Natl. Acad. Sci. U.S.A. 76:1288-1292(1979).

One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

Fogh J., Fogh J.M., Orfeo T.

J. Natl. Cancer Inst. 59:221-226(1977).

Web Resources