A-704Homo sapiens (Human)Cancer cell line

Also known as: A704, A.704

🤖 AI SummaryBased on 14 publications

Quick Overview

A-704 is a human kidney epithelial cell line used in cancer research.

Detailed Summary

A-704 is a human kidney epithelial cell line derived from a renal carcinoma. It is commonly used in studies related to renal cell carcinoma (RCC) and has been characterized in various genomic and molecular studies. This cell line is notable for its role in understanding the genetic and molecular mechanisms underlying RCC, including alterations in tumor suppressor genes and chromosomal abnormalities. Research involving A-704 has contributed to the identification of key genetic markers and pathways associated with RCC progression and metastasis. The cell line is also utilized in drug sensitivity and resistance studies, providing insights into potential therapeutic targets for kidney cancer.

Research Applications

Renal cell carcinoma (RCC) researchGenomic and molecular characterization of RCCDrug sensitivity and resistance studiesIdentification of genetic markers and pathways in RCC

Key Characteristics

Derived from renal carcinomaUsed in studies of RCC genetics and molecular mechanismsNotable for chromosomal abnormalities and tumor suppressor gene alterations
Generated on 6/16/2025

Basic Information

Database IDCVCL_1065
SpeciesHomo sapiens (Human)
Tissue SourceKidney[UBERON:UBERON_0002113]

Donor Information

Age78
Age CategoryAdult
SexMale

Disease Information

DiseaseRenal cell carcinoma
LineageKidney
SubtypeRenal Cell Carcinoma
OncoTree CodeRCC

DepMap Information

Source TypeATCC
Source IDACH-000429_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Glu258Ter (c.772G>T)Unspecified-PubMed=27693639
MutationSimpleTP53p.Cys135Arg (c.403T>C)Heterozygous-Unknown
MutationSimpleTP53p.Tyr126Asp (c.376T>G)Heterozygous-Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
7,8
D13S317
8
D16S539
12,13
D18S51
16,17
D19S433
13
D21S11
28,32
D2S1338
16,21
D3S1358
15
D5S818
10,11
D7S820
10
D8S1179
13,15
FGA
22,23
Penta D
2.2,11
Penta E
8,17
TH01
7
TPOX
11
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.

Hsieh J.J.-D., Hakimi A.A.

Nat. Commun. 8:15165.1-15165.10(2017).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

Loss of PBRM1 expression is associated with renal cell carcinoma progression.

Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.

Int. J. Cancer 132:E11-E17(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Contribution of chromosome 9p21-22 deletion to the progression of human renal cell carcinoma.

Mishina M., Habuchi T., Takahashi R., Sugiyama T., Yoshida O.

Jpn. J. Cancer Res. 86:795-799(1995).

Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.

Yarosh D.B., Foote R.S., Mitra S., Day R.S. 3rd

Carcinogenesis 4:199-205(1983).

Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.

Gershwin M.E., Lentz D., Owens R.B.

Exp. Cell Biol. 52:361-370(1984).

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.

Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D.

Nature 288:724-727(1980).

Human urologic cancer cell lines.";

Williams R.D.

Invest. Urol. 17:359-363(1980).

Polymorphic enzyme analysis of cultured human tumor cell lines.";

Dracopoli N.C., Fogh J.

J. Natl. Cancer Inst. 70:469-476(1983).

In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.

Dosik H., Parks W.P.

J. Natl. Cancer Inst. 51:1417-1423(1973).

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.

Cancer Res. 48:589-601(1988).

Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors.

Fogh J.

Natl. Cancer Inst. Monogr. 49:5-9(1978).

Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N'-nitro-N-nitrosoguanidine-damaged adenovirus 5.

Day R.S. 3rd, Ziolkowski C.H.J.

Nature 279:797-799(1979).

Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.

Espmark J.A., Ahlqvist-Roth L., Sarne L., Persson A.

Tissue Antigens 11:279-286(1978).