AM-38Homo sapiens (Human)Cancer cell line

Also known as: AM, AM38

🤖 AI SummaryBased on 9 publications

Quick Overview

Human glioblastoma cell line with known genetic mutations and chemosensitivity profiles.

Detailed Summary

AM-38 is a human glioblastoma cell line derived from a glioblastoma tumor. It exhibits specific genetic characteristics, including mutations in key oncogenes and tumor suppressor genes, which are critical for understanding the molecular mechanisms of glioblastoma. The cell line has been characterized for its response to various chemotherapeutic agents, showing distinct sensitivity to drugs like ACNU. AM-38 is widely used in research to study the efficacy of targeted therapies and to investigate the role of specific genetic alterations in tumor progression and drug resistance. Its availability allows for the development of in vitro models to test new therapeutic strategies against glioblastoma.

Research Applications

Cancer drug screeningGenetic mutation analysisChemosensitivity testingTumor biology studies

Key Characteristics

Expresses GFAP and S-100 proteinsHigh MGMT activity in tumor specimensSensitivity to ACNU chemotherapyEstablished cell line with long-term culture capability

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1070
Species	Homo sapiens (Human)
Tissue Source	Brain, left occipital lobe[UBERON:UBERON_0002806]

Donor Information

Age	36
Age Category	Adult
Sex	Male

Disease Information

Disease	Glioblastoma
Lineage	CNS/Brain
Subtype	Glioblastoma
OncoTree Code	GB

DepMap Information

Source Type	HSRRB
Source ID	ACH-000269_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

D16S539

11,13

D18S51

D19S433

D21S11

D2S1338

19,24

D3S1358

D5S818

12,13

D7S820

D8S1179

13,14

FGA

23,25

Penta D

Penta E

5,18

TH01

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Aoyagi M., Ohno K., Imoto I., Inazawa J.

Cancer Sci. 96:676-683(2005).

DOI PubMed PMC

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

DOI PubMed

Characterization and chemosensitivity of two cell lines derived from human glioblastomas.

Izumu I., Mineura K., Watanabe K., Kowada M.

J. Neurooncol. 17:111-121(1993).

DOI PubMed

Establishment of the two glioma cell lines: YH and AM.";

Izumi I., Mineura K., Watanabe K., Kowada M.

Hum. Cell 7:101-105(1994).

PubMed