AML-193Homo sapiens (Human)Cancer cell line
Also known as: AML193
Quick Overview
AML-193 is a human acute myeloid leukemia cell line with JAK2 V617F mutation.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1071 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 13 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
Disease Information
| Disease | Acute myeloid leukemia |
|---|---|
| Lineage | Myeloid |
| Subtype | Acute Myeloid Leukemia |
| OncoTree Code | AML |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000557_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | c.993+2T>G (IVS9+2T>G) | Unspecified | Splice donor mutation | from parent cell line AML-193 |
| MutationSimple | NRAS | p.Gly13Val (c.38G>T) | Heterozygous | - | from parent cell line AML-193 |
| MutationSimple | BCORL1 | p.Arg784Ter (c.2350C>T) | Unspecified | - | from parent cell line AML-193 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Screening human cell lines for viral infections applying RNA-Seq data analysis.
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
PLoS ONE 14:E0210404-E0210404(2019).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia.
Vogelstein B., Kinzler K.W., Papadopoulos N., Malek S.N.
Blood 118:5914-5917(2011).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
Leukemia 20:471-476(2006).
Mutations of the BRAF gene in human cancer.";
Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Nature 417:949-954(2002).
Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines.
Rovera G.
Blood 70:192-199(1987).
Origins and properties of hematopoietic growth factor-dependent cell lines.
Ihle J.N., Askew D.
Int. J. Cell Cloning 7:68-91(1989).
Two-step differentiation of AML-193 leukemic line: terminal maturation is induced by positive interaction of retinoic acid with granulocyte colony-stimulating factor (CSF) and vitamin D3 with monocyte CSF.
Valtieri M., Boccoli G., Testa U., Barletta C., Peschle C.
Blood 77:1804-1812(1991).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).