BC-1Homo sapiens (Human)Cancer cell line

Also known as: BC1

🤖 AI SummaryBased on 8 publications

Quick Overview

BC-1 is a human B-cell lymphoma cell line associated with Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus...

Detailed Summary

BC-1 is a human B-cell lymphoma cell line derived from primary effusion lymphoma (PEL) and is known to be infected with Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). This cell line is widely used in research to study the molecular mechanisms of PEL, including the role of viral infections in tumorigenesis and the impact of KSHV and EBV on cellular gene expression. BC-1 has been utilized in studies examining the functional consequences of p53 mutations and the effectiveness of chemotherapeutic agents like doxorubicin. Additionally, BC-1 is a valuable model for investigating the genetic and molecular alterations associated with PEL, such as deletions in tumor suppressor genes like FHIT and WWOX, and the role of these alterations in cancer progression.

Research Applications

Study of Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) infections in PELInvestigation of p53 mutations and their impact on cancer progressionEvaluation of chemotherapeutic drug efficacy, such as doxorubicinAnalysis of genetic alterations in tumor suppressor genes like FHIT and WWOXCharacterization of viral and cellular gene expression profiles in PEL

Key Characteristics

Infected with KSHV and EBVUsed for studying PEL pathogenesisRelevant for understanding viral contributions to tumorigenesisModel for investigating genetic and molecular alterations in PEL

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1079
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Donor Information

Age	46
Age Category	Adult
Sex	Male

Disease Information

Disease	Primary effusion lymphoma
Lineage	Lymphoid
Subtype	Primary Effusion Lymphoma
OncoTree Code	PEL

DepMap Information

Source Type	ATCC
Source ID	ACH-002214_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,11

D13S317

D16S539

12,13

D18S51

12,15

D19S433

13,14

D21S11

28,30

D2S1338

19,23

D3S1358

14,15

D5S818

11,12

D7S820

D8S1179

14,16

FGA

22,23

Penta D

Penta E

11,12

TH01

9.3

TPOX

8,9

vWA

16,20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

The Epstein-Barr virus enhancer interaction landscapes in virus-associated cancer cell lines.

Jin S.-L., Sato Y., Zhao B.

J. Virol. 96:e00739.22.1-e00739.22.11(2022).

DOI PubMed PMC

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.

Roy D., Sin S.-H., Damania B., Dittmer D.P.

Blood 118:e32-e39(2011).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.

Burd C.E., Sin S.-H., Dittmer D.P.

J. Virol. 81:1912-1922(2007).

DOI PubMed PMC

Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.

Knowles D.M.

J. Virol. 79:1244-1251(2005).

DOI PubMed PMC

Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas).

Drexler H.G., Uphoff C.C., Gaidano G., Carbone A.

Leukemia 12:1507-1517(1998).

DOI PubMed

Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae.

Knowles D.M., Garber R., Pellett P.E., McGeoch D.J., Chang Y.

J. Virol. 70:549-558(1996).

DOI PubMed PMC

In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences.

Chang Y.

Blood 86:2708-2714(1995).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

cells-talk.com