BC-3Homo sapiens (Human)Cancer cell line

Also known as: BC3

🤖 AI SummaryBased on 10 publications

Quick Overview

BC-3 is a primary effusion lymphoma cell line associated with Kaposi's sarcoma-associated herpesvirus (KSHV) and lacking Epstei...

Detailed Summary

BC-3 is a primary effusion lymphoma (PEL) cell line established from a lymphomatous effusion of an HIV-negative patient. It is characterized by the presence of Kaposi's sarcoma-associated herpesvirus (KSHV) and the absence of Epstein-Barr virus (EBV) infection. This cell line is used in research to study the molecular mechanisms of PEL, including the role of KSHV in tumorigenesis and the impact of viral infections on cellular processes. BC-3 is also utilized to investigate the genetic and molecular alterations associated with PEL, such as mutations in tumor suppressor genes and the activation of signaling pathways. The cell line provides a valuable model for understanding the pathogenesis of PEL and for developing targeted therapies.

Research Applications

Study of Kaposi's sarcoma-associated herpesvirus (KSHV) in PELInvestigation of molecular mechanisms of PEL pathogenesisAnalysis of genetic and molecular alterations in PELDevelopment of targeted therapies for PEL

Key Characteristics

KSHV-positiveEBV-negativePrimary effusion lymphomaUsed in cancer research for understanding viral contributions to tumorigenesis

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1080
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	85
Age Category	Adult
Sex	Male

Disease Information

Disease	Primary effusion lymphoma
Lineage	Lymphoid
Subtype	Primary Effusion Lymphoma
OncoTree Code	PEL

DepMap Information

Source Type	ATCC
Source ID	ACH-002215_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
Gene deletion	CDKN2A	-	Homozygous	Possible	PubMed=26870271

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

D16S539

D18S51

14,21.2

D19S433

14,15

D21S11

29,30

D2S1338

24,25

D3S1358

15,17

D5S818

11,12

D7S820

10,12

D8S1179

14,16

FGA

18,22

Penta D

8,13

Penta E

7,15

TH01

6,9

TPOX

8,11

vWA

14,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.

Roy D., Sin S.-H., Damania B., Dittmer D.P.

Blood 118:e32-e39(2011).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/beta-catenin genes in human herpesvirus 8-associated primary effusion lymphoma.

Boulanger E., Marchio A., Hong S.-S., Pineau P.

Haematologica 94:1170-1174(2009).

DOI PubMed PMC

Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.

Burd C.E., Sin S.-H., Dittmer D.P.

J. Virol. 81:1912-1922(2007).

DOI PubMed PMC

Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.

Knowles D.M.

J. Virol. 79:1244-1251(2005).

DOI PubMed PMC

Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas).

Drexler H.G., Uphoff C.C., Gaidano G., Carbone A.

Leukemia 12:1507-1517(1998).

DOI PubMed

Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus.

Knowles D.M., Cesarman E.

Blood 88:2648-2654(1996).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

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