BHYHomo sapiens (Human)Cancer cell line
Quick Overview
Human oral squamous cell carcinoma cell line with known genetic alterations.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1086 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, alveolar ridge[UBERON:UBERON_0004103] |
Donor Information
| Age | 52 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000548_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Leu369Pro (c.1106T>C) | Unspecified | - | PubMed=17390010 |
| MutationSimple | TP53 | p.Met160Val (c.478A>G) | Unspecified | - | PubMed=17390010 |
| MutationSimple | TP53 | p.Thr118Glnfs*5 (c.351delG) (p.G117fs) | Unspecified | - | PubMed=28683746 |
| MutationUnexplicit | PARD3 | Ex6-15del | Homozygous | - | PubMed=20215515 |
| MutationSimple | CDKN2A | p.Arg58Ter (c.172C>T) (p.Pro72Leu, c.215C>T) | Unspecified | - | PubMed=9598804 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
Oncotarget 5:8906-8923(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Characterization of gene expression profiles of 3 different human oral squamous cell carcinoma cell lines with different invasion and metastatic capacities.
Erdem N.F., Carlson E.R., Gerard D.A.
J. Oral Maxillofac. Surg. 66:918-927(2008).
Characterization of 3 oral squamous cell carcinoma cell lines with different invasion and/or metastatic potentials.
Erdem N.F., Carlson E.R., Gerard D.A., Ichiki A.T.
J. Oral Maxillofac. Surg. 65:1725-1733(2007).
Oncogenic mutation of the p53 gene derived from head and neck cancer prevents cells from undergoing apoptosis after DNA damage.
Tachibana M., Imai Y., Fujimori T.
Int. J. Oncol. 30:1089-1097(2007).