BPH-1Homo sapiens (Human)Transformed cell line

Also known as: Benign Prostatic Hyperplasia-1, BPH1

🤖 AI SummaryBased on 6 publications

Quick Overview

BPH-1 is a non-transformed human prostate epithelial cell line used in cancer research.

Detailed Summary

BPH-1 is an immortalized but non-transformed human prostate epithelial cell line derived from benign prostatic hyperplasia (BPH) tissue. It retains some characteristics of normal prostatic epithelium, including the expression of cytokeratins 7, 8, and 19, and lacks expression of androgen receptors and prostate-specific antigens. The cell line is non-tumorigenic in nude mice and exhibits a cobblestone morphology in culture. BPH-1 has been used to study androgen metabolism, cell proliferation, and the role of cell polarity in prostate cancer development. It is also utilized in research on the effects of growth factors and hormonal influences on prostate epithelial cells.

Research Applications

Androgen metabolism studiesCell proliferation analysisCell polarity and cancer developmentGrowth factor and hormone response studies

Key Characteristics

Non-tumorigenic in nude miceCobblestone morphology in cultureExpression of cytokeratins 7, 8, and 19Lack of androgen receptor expressionImmortalized but non-transformed

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1091
Species	Homo sapiens (Human)
Tissue Source	Prostate[UBERON:UBERON_0002367]

Donor Information

Age	68
Age Category	Adult
Sex	Male

Disease Information

Disease	Benign prostatic hyperplasia
Lineage	Fibroblast
Subtype	Fibroblast, Soft Tissue

DepMap Information

Source Type	DSMZ
Source ID	ACH-001453_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

11,12

D16S539

D18S51

10,16

D19S433

12,15

D21S11

28,32.2

D2S1338

D3S1358

D5S818

11,12

D7S820

10,11

D8S1179

10,15

FGA

21,24

Penta D

9,14

Penta E

7,10

TH01

6,7

TPOX

8,12

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression.

Li Y.-M., Alsagabi M., Fan D.-H., Bova G.S., Tewfik A.H., Dehm S.M.

Cancer Res. 71:2108-2117(2011).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis.

Rivera A., Linehan W.M., Cunha G.R., Ried T.

Cancer Res. 61:8143-8149(2001).

PubMed

Widely used prostate carcinoma cell lines share common origins.";

van Bokhoven A., Varella-Garcia M., Korch C.T., Hessels D., Miller G.J.

Prostate 47:36-51(2001).

DOI PubMed

Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1.

Narayan P.

In Vitro Cell. Dev. Biol. Anim. 31:14-24(1995).

DOI PubMed

Web Resources

web.archive.org