BeckerHomo sapiens (Human)Cancer cell line

Also known as: AK, BECKER

🤖 AI SummaryBased on 6 publications

Quick Overview

Human astrocytoma cell line for cancer research

Detailed Summary

The Becker cell line is a human astrocytoma-derived cell line used in cancer research. It was characterized in studies focusing on cell surface antigens and their role in tumor biology. Research has identified specific antigens associated with this cell line, including AJ and class II antigens, which are relevant to understanding tumor immunology and potential therapeutic targets. The cell line has been utilized in studies involving serological analysis and drug sensitivity profiling, contributing to the development of predictive models for cancer treatment. Its use in genomic and molecular studies has provided insights into the genetic and molecular mechanisms underlying astrocytoma progression and response to therapies.

Research Applications

Cancer researchTumor immunologyDrug sensitivity profilingGenomic and molecular studies

Key Characteristics

Expression of AJ and class II antigensUsed in serological analysis of cell surface antigensContributed to predictive models for cancer treatment

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1093
Species	Homo sapiens (Human)
Tissue Source	Brain[UBERON:UBERON_0000955]

Donor Information

Age	57
Age Category	Adult
Sex	Male

Disease Information

Disease	Astrocytoma
Lineage	CNS/Brain
Subtype	Astrocytoma
OncoTree Code	ASTR

DepMap Information

Source Type	HSRRB
Source ID	ACH-001016_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21)	Unspecified	Splice acceptor mutation	from parent cell line U-1285

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

12,13

D13S317

D16S539

10,14

D5S818

D7S820

TH01

8,9

TPOX

8,11

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Aoyagi M., Ohno K., Imoto I., Inazawa J.

Cancer Sci. 96:676-683(2005).

DOI PubMed PMC

Serological analysis of cell surface antigens of malignant human brain tumors.

Oettgen H.F., Old L.J.

Proc. Natl. Acad. Sci. U.S.A. 75:5122-5126(1978).

DOI PubMed PMC