C-4-IIHomo sapiens (Human)Cancer cell line

Also known as: C4II, C4 II, C-4II, C-4 II

🤖 AI SummaryBased on 9 publications

Quick Overview

C-4-II is a human cervical squamous carcinoma cell line with known Smad4 deficiency and potential for in vitro and in vivo stud...

Detailed Summary

C-4-II is a human cervical squamous carcinoma cell line derived from a poorly differentiated invasive carcinoma. It exhibits Smad4 deficiency, which is associated with resistance to TGF-β signaling. The cell line has been used in studies examining the molecular mechanisms of cervical carcinogenesis and the role of Smad4 in tumor progression. C-4-II demonstrates distinct growth patterns in vitro, forming spreading, mono-layered epithelial colonies. It has also been utilized in investigations of chromosomal alterations and their implications in cancer development. The cell line's characteristics make it a valuable tool for studying the genetic and molecular basis of cervical cancer.

Research Applications

Analysis of Smad4 deficiency and TGF-β resistanceIn vitro and in vivo studies of cervical carcinogenesisChromosomal alterations and cancer developmentMolecular mechanisms of tumor progression

Key Characteristics

Smad4 deficiencyInvasive growth patternsDistinct in vitro colony formationPotential for studying TGF-β signaling pathways

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1095
Species	Homo sapiens (Human)
Tissue Source	Uterus, cervix[UBERON:UBERON_0000002]

Donor Information

Age	41
Age Category	Adult
Sex	Female

Disease Information

Disease	Squamous cell carcinoma of the cervix uteri
Lineage	Cervix
Subtype	Cervical Squamous Cell Carcinoma
OncoTree Code	CESC

DepMap Information

Source Type	ATCC
Source ID	ACH-001335_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

11,12

D16S539

D18S51

D19S433

13,14

D21S11

29,30

D2S1338

D3S1358

16,17

D5S818

9,11

D7S820

10,11

D8S1179

14,15

FGA

Penta D

9,13

Penta E

TH01

9,9.3

TPOX

10,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Establishment, authenticity, and characterization of cervical cancer cell lines.

Garcia-Carranca A.M., Cerbon-Cervantes M.A., Alcantara-Quintana L.E.

Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022).

DOI PubMed PMC

Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.

Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.

Oncotarget 8:86369-86383(2017).

DOI PubMed PMC

Individual karyotypes at the origins of cervical carcinomas.";

Duesberg P.H.

Mol. Cytogenet. 6:44.1-44.23(2013).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Smad4 deficiency in cervical carcinoma cells.";

Schwarte-Waldhoff I.

Oncogene 24:810-819(2005).

DOI PubMed

Long-term cultivation of hypodiploid human tumor cells.";

Auersperg N.

J. Natl. Cancer Inst. 32:135-163(1964).

DOI PubMed

Chromosome observations on three epithelial-cell cultures derived from carcinomas of the human cervix.

Auersperg N., Hawryluk A.P.

J. Natl. Cancer Inst. 28:605-627(1962).

DOI PubMed

Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.

Wright W.C., Daniels W.P., Fogh J.

J. Natl. Cancer Inst. 66:239-247(1981).

DOI PubMed

Histogenetic behavior of tumors. I. Morphologic variation in vitro and in vivo of two related human carcinoma cell lines.

Auersperg N.

J. Natl. Cancer Inst. 43:151-173(1969).

DOI PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOI PubMed

Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.

Am. J. Pathol. 119:361-366(1985).

PubMed PMC

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Fogh J., Wright W.C., Loveless J.D.

J. Natl. Cancer Inst. 58:209-214(1977).

DOI PubMed