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C2BBe1Homo sapiens (Human)Cancer cell line

Also known as: Caco-2 Brush Border expressing 1, BBE, CACO2BBE, Caco2BBE, Caco2BBe, Caco2-BBE, Caco-2 BBe, Caco-2BBE, Caco-2BBe, Caco-2/BBe, Caco-2/BBe 1, C2BBe 1, C2BBE1

🤖 AI SummaryBased on 11 publications

Quick Overview

C2BBe1 is a human colorectal cancer cell line used in cancer research.

Detailed Summary

C2BBe1 is a human colorectal cancer cell line derived from a primary tumor. It is widely used in research to study the molecular mechanisms of colorectal cancer, including the effects of genetic mutations and drug responses. This cell line has been utilized in studies related to KRAS mutations, mismatch repair deficiency, and 5-fluorouracil sensitivity. Its genetic profile and response to various treatments make it a valuable model for understanding cancer biology and developing targeted therapies.

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1096
Species	Homo sapiens (Human)
Tissue Source	Colon[UBERON:UBERON_0001155]

Donor Information

Age	72
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Colon adenocarcinoma
Lineage	Bowel
Subtype	Colon Adenocarcinoma
OncoTree Code	COAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000009_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Glu204Ter (c.610G>T)	Unspecified	-	PubMed=12377411
MutationSimple	SMAD4	p.Asp351His (c.1051G>C)	Homozygous	-	from parent cell line Caco-2
MutationSimple	CTNNB1	p.Gly245Ala (c.734G>C)	Heterozygous	-	from parent cell line Caco-2
MutationSimple	APC	p.Gln1367Ter (c.4099C>T)	Homozygous	-	from parent cell line Caco-2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

11

D13S317

8,11,13,14

D16S539

12,13

D18S51

12

D19S433

15

D21S11

30

D2S1338

17,25

D3S1358

14,17

D5S818

12,13

D7S820

11,12

D8S1179

12,14

FGA

19

Penta D

9,11

Penta E

7

TH01

6

TPOX

9,11

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

Genomic determinants of protein abundance variation in colorectal cancer cells.

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.

Cell Rep. 20:2201-2214(2017).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Zinc finger nuclease-mediated gene knockout results in loss of transport activity for P-glycoprotein, BCRP, and MRP2 in Caco-2 cells.

Blasberg J., Steiner T., Bourner M., Thompson D.C.

Drug Metab. Dispos. 43:199-207(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.

Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.

Br. J. Cancer 103:340-346(2010).

Genomic and biological characterization of exon 4 KRAS mutations in human cancer.

Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.

Cancer Res. 70:5901-5911(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics.

Zucco F.

Cell Biol. Toxicol. 21:1-26(2005).

Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2.

Peterson M.D., Mooseker M.S.

J. Cell Sci. 102:581-600(1992).

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