C8166Homo sapiens (Human)Transformed cell line
Also known as: C8166-CD4
🤖 AI SummaryBased on 5 publications
Quick Overview
Human T-cell leukemia cell line with HTLV-1 infection
Detailed Summary
The C8166 cell line is a human T-cell leukemia cell line derived from a patient with adult T-cell leukemia (ATL). It is known for its susceptibility to human T-cell leukemia virus type 1 (HTLV-1) infection and is widely used in research related to HTLV-1 pathogenesis and oncogenesis. This cell line exhibits characteristics of transformed T-cells, including uncontrolled proliferation and resistance to apoptosis. C8166 has been utilized in studies investigating the molecular mechanisms of HTLV-1-induced transformation, viral replication, and the role of the Tax protein in oncogenic processes. Additionally, it has been employed in the development of therapeutic strategies targeting HTLV-1-associated malignancies.
Research Applications
HTLV-1 infection and pathogenesisOncogenesis and tumor transformationViral replication and gene expressionTherapeutic target identification
Key Characteristics
HTLV-1 infectedTransformed T-cellsUncontrolled proliferationResistance to apoptosis
Generated on 6/16/2025
Basic Information
| Database ID | CVCL_1099 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Umbilical cord blood[UBERON:UBERON_0012168] |
Donor Information
| Age Category | Fetus |
|---|---|
| Sex | Male |
Disease Information
| Disease | T-Lymphoblastic Leukemia/Lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | T-Lymphoblastic Leukemia/Lymphoma |
| OncoTree Code | TLL |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-000206_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | NRAS | p.Gln61Lys (c.181C>A) | Unspecified | Acquired during resistance selection process | PubMed=26214590 |
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines.
Shimozato O., Taylor G.P., Bangham C.R.M., Derse D.D.
Blood 102:4130-4136(2003).