Ca SkiHomo sapiens (Human)Cancer cell line
Also known as: CASKI, Caski, CaSki, Ca-Ski
Quick Overview
Cervical cancer cell line with HPV16 infection, used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1100 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Small intestine[UBERON:UBERON_0002108] |
Donor Information
| Age | 40 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Squamous cell carcinoma of the cervix uteri |
|---|---|
| Lineage | Cervix |
| Subtype | Cervical Squamous Cell Carcinoma |
| OncoTree Code | CESC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001336_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationNone reported | TP53 | - | - | - | PubMed=19787792 |
| MutationSimple | PIK3CA | p.Glu545Lys (c.1633G>A) | Heterozygous | - | from parent cell line MCF-7 |
| MutationSimple | KMT2D | p.Gln4079Ter (c.12235C>T) | Heterozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Oncotarget 8:86369-86383(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Symer D.E., Gillison M.L.
Genome Res. 24:185-199(2014).
Individual karyotypes at the origins of cervical carcinomas.";
Duesberg P.H.
Mol. Cytogenet. 6:44.1-44.23(2013).
Amplified genes may be overexpressed, unchanged, or downregulated in cervical cancer cell lines.
Rangel-Lopez A., Kofman S., Berumen J.
PLoS ONE 7:E32667-E32667(2012).
The HPV transcriptome in HPV16 positive cell lines.";
Schmitt M., Pawlita M.
Mol. Cell. Probes 25:108-113(2011).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Biological properties of Caski cell lines induced by exposing to the space environment.
Yang C., Li G.-C., Li Y.-H., Hu J.-Y., Xiao Y., Zhang Z.-J.
Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:380-386(2007).
Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.
Gorter A., Kenter G.G., Fleuren G.J., Jordanova E.S.
BMC Genomics 8:53.1-53.13(2007).
Smad4 deficiency in cervical carcinoma cells.";
Schwarte-Waldhoff I.
Oncogene 24:810-819(2005).
Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines.
Meissner J.D.
J. Gen. Virol. 80:1725-1733(1999).
p53 mutations and presence of HPV DNA do not correlate with radiosensitivity of gynecological cancer cell lines.
Syrjanen S.M.
Gynecol. Oncol. 71:352-358(1998).
The intrinsic radiosensitivity and sublethal damage repair capacity of five cervical carcinoma cell lines tested with the 96-well-plate assay.
Rantanen V., Grenman S.E., Kulmala J., Grenman R.
J. Cancer Res. Clin. Oncol. 121:230-234(1995).
In vitro response of cervical cancer cell lines CaSki, HeLa, and ME-180 to the antiestrogen tamoxifen.
Grenman S.E., Shapira A., Carey T.E.
Gynecol. Oncol. 30:228-238(1988).
Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines.
Howley P.M.
J. Virol. 61:962-971(1987).
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Am. J. Pathol. 119:361-366(1985).