Ca9-22Homo sapiens (Human)Cancer cell line
Also known as: Ca922, CA922, Ca 9-22, CA9-22
Quick Overview
Human oral squamous cell carcinoma cell line with E-cadherin expression and potential for cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1102 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, gingiva[UBERON:UBERON_0001828] |
Donor Information
| Age | 43 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-002043_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Trp (c.742C>T) | Homozygous | Somatic mutation acquired during proliferation | from parent cell line VCaP |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Oncotarget 8:86369-86383(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Clin. Cancer Res. 17:7248-7264(2011).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.
Sasaki K., Hanazawa T., Okamoto Y., Hata A.
Genes Chromosomes Cancer 48:132-142(2009).
Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.
Murugan A.K., Hong N.T., Fukui Y., Munirajan A.K., Tsuchida N.
Int. J. Oncol. 32:101-111(2008).
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Kozaki K.-i., Amagasa T., Inazawa J.
Oncogene 26:7921-7932(2007).
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Hamakawa H.
Oncogene 26:5300-5308(2007).
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.
Omura K., Inazawa J.
Cancer Sci. 97:1351-1358(2006).
Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium.
Sugiyama M., Bhawal U.K., Dohmen T., Ono S., Miyauchi M., Ishikawa T.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 95:594-600(2003).
A wild-type sequence p53 peptide presented by HLA-A24 induces cytotoxic T lymphocytes that recognize squamous cell carcinomas of the head and neck.
Song Y.-S., Appella E., Whiteside T.L., DeLeo A.B.
Clin. Cancer Res. 6:979-986(2000).
Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo.
Hoteiya T., Hayashi E., Satomura K., Kamata N., Nagayama M.
J. Oral Pathol. Med. 28:107-111(1999).
Screening the p53 status of human cell lines using a yeast functional assay.
Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Mol. Carcinog. 19:243-253(1997).
Expression of bone morphogenetic proteins of human neoplastic epithelial cells.
Hatakeyama S., Gao Y.-H., Ohara-Nemoto Y., Kataoka H., Satoh M.
Biochem. Mol. Biol. Int. 42:497-505(1997).
CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.
Itoh K.
Cell. Immunol. 177:176-181(1997).
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
Cell. Immunol. 175:101-110(1997).
A new human cell line derived from human carcinoma of the gingiva. I. Its establishment and morphological studies.
Horikoshi M., Kimura Y., Nagura H., Ono T., Ito H.
Nihon Koku Geka Gakkai Zasshi 20:100-106(1974).
Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.
Rikimaru K., Toda H., Tachikawa N., Kamata N., Enomoto S.
In Vitro Cell. Dev. Biol. 26:849-856(1990).
Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.
Sakai E., Tsuchida N.
Oncogene 7:927-933(1992).
Studies on lactate dehydrogenase isoenzymes in a cell line (Ca 9-22) derived from carcinoma of the gingiva.
Kimura Y.
Kokubyo Gakkai Zasshi 45:20-35(1978).
Lymphocyte mediated cytotoxicity to oral squamous cell carcinoma cell line (Ca 9-22).
Horikoshi M., Katsumura A., Fujibayashi T., Soda T., Itoh H.
Nihon Koku Geka Gakkai Zasshi 23:619-625(1977).