CAL-12THomo sapiens (Human)Cancer cell line
Also known as: Centre Antoine Lacassagne-12T, CAL 12, Cal12T, CAL12T, CAL 12T, Cal.12T, Cal-12T
Quick Overview
Human cancer cell line with potential for drug sensitivity studies.
Detailed Summary
Basic Information
| Database ID | CVCL_1105 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Lung non-small cell carcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Non-Small Cell Lung Cancer |
| OncoTree Code | NSCLC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000826_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Cys135Phe (c.404G>T) | Heterozygous | - | PubMed=22170099, PubMed=19147553, PubMed=16142320 |
| MutationSimple | BRAF | p.Gly466Val (c.1397G>T) | Unspecified | - | PubMed=12068308 |
| MutationSimple | ARID2 | p.Gly1291Glufs*4 (c.3872del) (p.Val1290fs, c.3870delG) | Heterozygous | - | from parent cell line CAL-12T |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Posner B.A., Minna J.D., Kim H.S., White M.A.
Cell 173:864-878.e29(2018).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Zhou X.-M., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.
Cell 131:1190-1203(2007).
Characterization of a new surface epitope specific for human epithelial cells defined by a monoclonal antibody and application to tumor diagnosis.
Lalanne C.-M.
Cancer Res. 47:4417-4424(1987).
Epidermal growth factor receptor expression and suramin cytotoxicity in vitro.
Milano G.
Eur. J. Cancer 26:867-871(1990).