CAL-148Homo sapiens (Human)Cancer cell line

Also known as: Centre Antoine Lacassagne-148, CAL148, CAL 148

🤖 AI SummaryBased on 8 publications

Quick Overview

Human cancer cell line with potential for drug sensitivity studies.

Detailed Summary

CAL-148 is a human cancer cell line derived from an unspecified tissue and disease type. It is part of a large panel of cancer cell lines used for genomic and pharmacological studies. Research indicates that these cell lines are valuable for understanding drug response and identifying predictive biomarkers. The cell line is included in comprehensive studies that analyze gene expression, mutations, and drug sensitivity, contributing to the development of personalized cancer therapies. Its utility in preclinical models is highlighted by its inclusion in datasets like the Cancer Cell Line Encyclopedia (CCLE) and other large-scale genomic projects.

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1106
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	58
Age Category	Adult
Sex	Female
Subtype Features	luminal HER2+

Disease Information

Disease	Breast carcinoma
Lineage	Breast
Subtype	Breast Invasive Ductal Carcinoma
OncoTree Code	IDC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000902_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Glu224Lys (c.670G>A)	Heterozygous	-	PubMed=22570425

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11

D13S317

13,14

D16S539

D18S51

17,18

D19S433

13,14

D21S11

28,31.2

D2S1338

18,20

D3S1358

15,17

D5S818

D7S820

9,10

D8S1179

FGA

18,23

Penta D

11,14

Penta E

5,11

TH01

TPOX

8,11

vWA

17,19

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Modeling precision treatment of breast cancer.";

Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.

Genome Biol. 14:R110.1-R110.14(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Effects of tamoxifen on potential doubling time of human breast cancer cell line determined by image cytometry of double fluorescent BrdU and DNA labeling.

Lagrange J.-L., Gioanni J., Caldani C.

Anticancer Res. 14:2025-2032(1994).

PubMed

Web Resources

synapse.org tcpaportal.org