CAL-27Homo sapiens (Human)Cancer cell line
Also known as: Centre Antoine Lacassagne-27, CAL-SCC-27, Cal27, CAL27, Cal 27, CAL 27, Cal-27
Quick Overview
Human head and neck squamous cell carcinoma cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1107 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, tongue[UBERON:UBERON_0001723] |
Donor Information
| Age | 56 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Tongue adenosquamous carcinoma |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000832_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.His193Leu (c.578A>T) | Unspecified | - | PubMed=31541927, PubMed=23613873 |
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Fanconi anemia-isogenic head and neck cancer cell line pairs: a basic and translational science resource.
Smogorzewska A., Monnat R.J. Jr.
Int. J. Cancer 153:183-196(2023).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
The tongue squamous carcinoma cell line Cal27 primarily employs integrin alpha6beta4-containing type II hemidesmosomes for adhesion which contribute to anticancer drug sensitivity.
Ambriovic-Ristov A.
Front. Cell Dev. Biol. 9:786758.1-786758.17(2021).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Combination of IFITM1 knockdown and radiotherapy inhibits the growth of oral cancer.
Wang X.-L., Li X.-Y.
Cancer Sci. 109:3115-3128(2018).
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Oncotarget 8:86369-86383(2017).
Spheroid-based 3D cell cultures enable personalized therapy testing and drug discovery in head and neck cancer.
Schwenk-Zieger S., Stauber R.H., Baumeister P., Becker S.
Anticancer Res. 37:2201-2210(2017).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Integrin alphavbeta3 expression in tongue squamous carcinoma cells Cal27 confers anticancer drug resistance through loss of pSrc(Y418).
Osmak M., Ambriovic-Ristov A.
Biochim. Biophys. Acta 1863:1969-1978(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma.
Simons A.L.
Mol. Oncol. 9:1371-1383(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
Oncotarget 5:8906-8923(2014).
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Symer D.E., Gillison M.L.
Genome Res. 24:185-199(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Clin. Cancer Res. 17:7248-7264(2011).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Integrative molecular characterization of head and neck cancer cell model genomes.
Tsui I.F.L., Garnis C.
Head Neck 32:1143-1160(2010).
CAL 27 is an oral adenosquamous carcinoma cell line.";
Zeng X.
Oral Oncol. 45:e204-e207(2009).
Two new human tumor cell lines derived from squamous cell carcinomas of the tongue: establishment, characterization and response to cytotoxic treatment.
Courdi A.
Eur. J. Cancer Clin. Oncol. 24:1445-1455(1988).
Characterization of a new surface epitope specific for human epithelial cells defined by a monoclonal antibody and application to tumor diagnosis.
Lalanne C.-M.
Cancer Res. 47:4417-4424(1987).