CAL-33Homo sapiens (Human)Cancer cell line
Also known as: Centre Antoine Lacassagne-33, CAL-SCC-33, CAL33, CAL 33, Cal-33
Quick Overview
CAL-33 is a human cancer cell line used in research for various cancers.
Detailed Summary
Basic Information
| Database ID | CVCL_1108 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, tongue[UBERON:UBERON_0001723] |
Donor Information
| Age | 69 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral tongue |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000518_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg175His (c.524G>A) | Unspecified | Somatic mutation acquired during proliferation | from parent cell line YCC-3 |
| MutationSimple | TMPRSS2 | p.Gly8Val (c.23G>T) (c.-57+99G>T) | Heterozygous | - | PubMed=34339474 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Fanconi anemia-isogenic head and neck cancer cell line pairs: a basic and translational science resource.
Smogorzewska A., Monnat R.J. Jr.
Int. J. Cancer 153:183-196(2023).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies.
Safranko Z.M., Kurolt I.-C., Markotic A., Cicin-Sain L., Steenpass L.
PLoS ONE 16:E0255622-E0255622(2021).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
Oncotarget 5:8906-8923(2014).
Establishment and molecular cytogenetic characterization of a cell culture model of head and neck squamous cell carcinoma (HNSCC).
Huber R., Walch A., Zitzelsberger H.
Genes (Basel) 1:388-412(2010).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Two new human tumor cell lines derived from squamous cell carcinomas of the tongue: establishment, characterization and response to cytotoxic treatment.
Courdi A.
Eur. J. Cancer Clin. Oncol. 24:1445-1455(1988).
Characterization of a new surface epitope specific for human epithelial cells defined by a monoclonal antibody and application to tumor diagnosis.
Lalanne C.-M.
Cancer Res. 47:4417-4424(1987).