CAL-54Homo sapiens (Human)Cancer cell line

Also known as: Centre Antoine Lacassagne-54, CAL54, CAL 54

🤖 AI SummaryBased on 7 publications

Quick Overview

CAL-54 is a human kidney cancer cell line used in cancer research.

Detailed Summary

CAL-54 is a human kidney cancer cell line that has been extensively studied in various cancer research contexts. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its genomic and transcriptomic profiles. This cell line is notable for its role in studies related to renal cell carcinoma (RCC), particularly in understanding the molecular characteristics and genomic alterations associated with different subtypes of RCC. Research has shown that CAL-54 exhibits specific genetic features that make it a valuable model for studying the aggressiveness and molecular mechanisms of kidney cancer. It has been used in studies to identify potential therapeutic targets and to understand the genetic basis of drug sensitivity and resistance in RCC.

Research Applications

Genomic profiling of renal cell carcinomaIdentification of genetic mutations and copy number alterationsStudy of drug sensitivity and resistance in kidney cancerInvestigation of molecular mechanisms of renal cell carcinoma

Key Characteristics

Part of the Cancer Cell Line Encyclopedia (CCLE)Used in studies of renal cell carcinoma subtypesNotably associated with clear cell renal cell carcinoma (ccRCC)Exhibits specific genetic features relevant to cancer research

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1111
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	75
Age Category	Adult
Sex	Male

Disease Information

Disease	Renal cell carcinoma
Lineage	Kidney
Subtype	Renal Cell Carcinoma
OncoTree Code	RCC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000457_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

13,14

D16S539

D18S51

13,14

D19S433

D21S11

30.2

D2S1338

17,23

D3S1358

D5S818

11,13

D7S820

D8S1179

9,12

FGA

22,23

Penta D

10,13

Penta E

7,19

TH01

6,9

TPOX

8,9

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.

Hsieh J.J.-D., Hakimi A.A.

Nat. Commun. 8:15165.1-15165.10(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

CAL 54, a new cell line derived from a human renal carcinoma: characterization and radiosensitivity.

Lagrange J.-L., Duplay H., Caldani C., Courdi A.

Bull. Cancer 83:553-558(1996).

PubMed