CAL-62Homo sapiens (Human)Cancer cell line

Also known as: Centre Antoine Lacassagne-62, CAL62, Cal 62, CAL 62, Cal-62

🤖 AI SummaryBased on 8 publications

Quick Overview

CAL-62 is a human thyroid cancer cell line used in cancer research.

Detailed Summary

CAL-62 is a human thyroid cancer cell line derived from an anaplastic thyroid carcinoma. It is widely used in research to study the molecular mechanisms of thyroid cancer and to develop new therapeutic strategies. The cell line has been characterized for its genetic mutations, including alterations in the TERT promoter, which are associated with advanced stages of the disease. CAL-62 is also used to investigate the role of cell polarity genes such as PARD3 in cancer progression. Researchers utilize this cell line to understand the genetic and molecular changes that contribute to thyroid cancer aggressiveness and to test potential targeted therapies.

Research Applications

Study of thyroid cancer molecular mechanismsDevelopment of targeted therapiesInvestigation of TERT promoter mutationsAnalysis of cell polarity gene alterations

Key Characteristics

Presence of TERT promoter mutationsAlterations in PARD3 geneUsed for in vitro studies of thyroid cancer

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1112
Species	Homo sapiens (Human)
Tissue Source	Thyroid gland[UBERON:UBERON_0002046]

Donor Information

Age	70
Age Category	Adult
Sex	Female

Disease Information

Disease	Anaplastic thyroid carcinoma
Lineage	Thyroid
Subtype	Anaplastic Thyroid Cancer
OncoTree Code	THAP

DepMap Information

Source Type	DSMZ
Source ID	ACH-000174_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ala161Asp (c.482C>A)	Unspecified	-	PubMed=16541312
MutationSimple	NF2	p.Glu215Ter (c.643G>T)	Homozygous	-	PubMed=30737244
MutationSimple	KRAS	p.Gly12Arg (c.34G>C)	Unspecified	-	PubMed=26124327
MutationSimple	EP300	p.Asp1485fs (c.4454delA)	Homozygous	-	PubMed=30737244
MutationSimple	CREBBP	p.Glu1541Ter (c.4621G>T)	Heterozygous	-	PubMed=30737244

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

9,12

D13S317

D16S539

12,13

D18S51

D19S433

D21S11

32.2

D2S1338

19,23

D3S1358

D5S818

9,12

D7S820

D8S1179

FGA

Penta D

Penta E

5,10

TH01

7,9

TPOX

8,9

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.

Fagin J.A., Schweppe R.E.

Clin. Cancer Res. 25:3141-3151(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Establishment and characterization of novel human primary and metastatic anaplastic thyroid cancer cell lines and their genomic evolution over a year as a primagraft.

Liu L.-Z., Tan K.-T., Chang W.J., Yang H.H., Ogawa S., Koeffler H.P.

J. Clin. Endocrinol. Metab. 100:725-735(2015).

DOI PubMed PMC

Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.

Ibrahimpasic T., Ghossein R.A., Fagin J.A.

J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.

Haugen B.R.

J. Clin. Endocrinol. Metab. 93:4331-4341(2008).

DOI PubMed PMC

Characterization of a human cell line from an anaplastic carcinoma of the thyroid gland.

Farges M.-F., Lambert J.-C., Duplay H., Schneider M.

Bull. Cancer 78:1053-1062(1991).

PubMed