CAL-72Homo sapiens (Human)Cancer cell line

Also known as: Centre Antoine Lacassagne-72, Cal72, CAL72, CAL 72

🤖 AI SummaryBased on 5 publications

Quick Overview

Human osteosarcoma cell line with unique effects on hematopoietic cells.

Detailed Summary

CAL-72 is a human osteosarcoma cell line that exhibits distinct effects on hematopoietic cells. It supports the proliferation of immature hematopoietic progenitors and induces monocytic differentiation of HL-60 cells more effectively than other osteosarcoma cell lines. CAL-72 expresses a unique cytokine and chemokine profile, including GM-CSF, G-CSF, TNF-α, IL-6, and MIP-1α, which may contribute to its supportive role in hematopoiesis. This cell line is valuable for studying the interactions between osteoblastic and hematopoietic cells in the bone marrow microenvironment.

Research Applications

Hematopoietic cell differentiationOsteoblast-hematopoietic cell interactionsCytokine and chemokine profiling

Key Characteristics

Supports hematopoietic progenitor expansionInduces monocytic differentiation of HL-60 cellsUnique cytokine expression profile

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1113
Species	Homo sapiens (Human)
Tissue Source	Bone, patella[UBERON:UBERON_0002446]

Donor Information

Age	10
Age Category	Pediatric
Sex	Male

Disease Information

Disease	Osteosarcoma
Lineage	Bone
Subtype	Osteosarcoma
OncoTree Code	OS

DepMap Information

Source Type	DSMZ
Source ID	ACH-001715_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,11

D13S317

D16S539

D18S51

D19S433

D21S11

D2S1338

D3S1358

D5S818

D7S820

D8S1179

11,14

FGA

19,22

Penta D

Penta E

15,19

TH01

TPOX

vWA

15,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

CAL72: a human osteosarcoma cell line with unique effects on hematopoietic cells.

Rochet N., Leroy P., Far D.F., Ollier L., Loubat A., Rossi B.

Eur. J. Haematol. 70:43-52(2003).

DOI PubMed

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

DOI PubMed

Establishment, characterisation and partial cytokine expression profile of a new human osteosarcoma cell line (CAL 72).

Gioanni J.

Int. J. Cancer 82:282-285(1999).

DOI PubMed