CCF-STTG1Homo sapiens (Human)Cancer cell line

Also known as: STTG1, CCFSTTG1

🤖 AI SummaryBased on 8 publications

Quick Overview

Human astrocytoma cell line for cancer research.

Detailed Summary

The CCF-STTG1 cell line is a human astrocytoma cell line derived from a brain tumor. It is used in research to study the molecular mechanisms of cancer, particularly in the context of gliomas and other brain tumors. This cell line is known for its ability to secrete apolipoprotein E, which is relevant to lipid metabolism and neurological functions. It is also utilized in studies involving the effects of insulin, lipids, and other hormones on cell behavior and gene expression. The cell line has been characterized for its genetic and molecular properties, making it a valuable tool for investigating the role of specific genes and pathways in cancer progression and treatment response.

Research Applications

Cancer researchLipid metabolism studiesGene expression analysisDrug response studies

Key Characteristics

Secretes apolipoprotein EResponsive to insulin and lipidsUsed in studies of brain tumors

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1118
Species	Homo sapiens (Human)
Tissue Source	Brain[UBERON:UBERON_0000955]

Donor Information

Age	68
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Astrocytoma
Lineage	CNS/Brain
Subtype	Astrocytoma
OncoTree Code	ASTR

DepMap Information

Source Type	ATCC
Source ID	ACH-000329_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationNone reported	IDH1	-	-	-	PubMed=19435942

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

11,13

D16S539

11,12

D18S51

D19S433

15.2,16

D21S11

28,29

D2S1338

20,26

D3S1358

16,17

D5S818

12,13

D7S820

10,11

D8S1179

13,14

FGA

20,22

Penta D

11,13

Penta E

TH01

7,8

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.

Jones D.T.W., Collins V.P.

Neuro-oncol. 11:341-347(2009).

DOI PubMed PMC

Enhanced DNA synthesis of human glial cells exposed to human leukocyte products.

Barna B.P., Chou S.M., Jacobs B., Ransohoff R.M., Hahn J.F., Bay J.W.

J. Neuroimmunol. 10:151-158(1985).

DOI PubMed

Secretion of apolipoprotein E by an astrocytoma cell line.";

Krul E.S., Tang J.

J. Neurosci. Res. 32:227-238(1992).

DOI PubMed

Brain tumors.";

Ali-Osman F.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).

DOI