ChaGo-K-1Homo sapiens (Human)Cancer cell line

Also known as: ChaGoK1, CHAGOK1, ChaGo-K1, ChaGo K-1, CHAGO-K-1

🤖 AI SummaryBased on 7 publications

Quick Overview

Human cancer cell line with potential for drug sensitivity studies.

Detailed Summary

ChaGo-K-1 is a human cancer cell line derived from a lung carcinoma. It has been identified as a clonal strain with high secretion rates of the alpha subunit of human chorionic gonadotropin (HCG). This cell line is notable for its ability to secrete significant amounts of HCG-alpha, which may have implications for understanding tumor biology and therapeutic targeting. The cell line has been used in studies related to hormone production and cancer cell behavior, particularly in the context of lung and placental cancers. Research on ChaGo-K-1 has contributed to the understanding of ectopic hormone production in cancer cells and the role of specific genetic mutations in tumor development.

Research Applications

Drug sensitivity studiesHormone production in cancerEctopic hormone productionTumor biology and development

Key Characteristics

High secretion of HCG-alphaClonal strainLung carcinoma origin

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1121
Species	Homo sapiens (Human)
Tissue Source	Hypodermis[UBERON:UBERON_0002072]

Donor Information

Age	45
Age Category	Adult
Sex	Male

Disease Information

Disease	Bronchogenic carcinoma
Lineage	Lung
Subtype	Non-Small Cell Lung Cancer
OncoTree Code	NSCLC

DepMap Information

Source Type	ECACC
Source ID	ACH-000867_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys275Phe (c.824G>T)	Homozygous	-	PubMed=29970484, PubMed=8782485, PubMed=8725545
MutationSimple	RB1	p.Glu837Lys (c.2509G>A)	Homozygous	-	Unknown, Unknown
MutationSimple	ARID1A	p.His684Asp (c.2050C>G)	Heterozygous	-	Unknown, Unknown
MutationSimple	ARID1A	c.1921-2A>G	Heterozygous	Splice acceptor mutation	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

D18S51

13,20

D19S433

14,14.2

D21S11

31.2,32

D2S1338

20,23

D3S1358

D5S818

D7S820

8,12

D8S1179

11,12

FGA

Penta D

9,13

Penta E

11,12

TH01

9.3

TPOX

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Ectopic and eutopic secretion of chorionic gonadotropin and its subunits in vitro: comparison of clonal strains from carcinomas of lung and placenta.

Rosen S.W.

J. Natl. Cancer Inst. 56:911-917(1976).

DOI PubMed