CHP-212Homo sapiens (Human)Cancer cell line
Also known as: Children's Hospital of Philadelphia-212, NB-9, NB9, CHP212, CHP 212
Quick Overview
Human neuroblastoma cell line with MYCN amplification and chromosomal abnormalities.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1125 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain[UBERON:UBERON_0000955] |
Donor Information
| Age | 1 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
| Subtype Features | MYC_Amplified |
Disease Information
| Disease | Neuroblastoma |
|---|---|
| Lineage | Peripheral Nervous System |
| Subtype | Neuroblastoma |
| OncoTree Code | NBL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000120_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | NRAS | p.Gln61Lys (c.181C>A) | Unspecified | Acquired during resistance selection process | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity.
Henssen A.G., Schwarz R.F., Haase K.
Cell Rep. 43:114711.1-114711.19(2024).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Sci. Data 4:170033-170033(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Identification of ALK as a major familial neuroblastoma predisposition gene.
Maris J.M.
Nature 455:930-935(2008).
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Maris J.M.
Genes Chromosomes Cancer 43:390-403(2005).
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Biedler J.L., Cheung N.-K.V., Ross R.A.
Neoplasia 6:838-845(2004).
Mutations of the BRAF gene in human cancer.";
Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Nature 417:949-954(2002).
Abnormalities of chromosome 1p in human neuroblastoma tumors and cell lines.
Schlesinger H.R.
Cancer Genet. Cytogenet. 7:33-42(1982).
Neuronal properties of neuroectodermal tumors in vitro.";
Schlesinger H.R., Rorke-Adams L.B., Jamieson R., Hummeler K.
Cancer Res. 41:2573-2575(1981).
Tumor cell lines of the peripheral nervous system.";
Israel M.A., Thiele C.J.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
Biedler J.L., Meyers M.B., Spengler B.A.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff S., Hertz L. (eds.); pp.267-307; Academic Press; New York; USA (1983).
Neuroblastoma.";
Thiele C.J.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).