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CML-T1Homo sapiens (Human)Cancer cell line

Also known as: CMLT1, CMLT-1, CML T1

🤖 AI SummaryBased on 12 publications

Quick Overview

CML-T1 is a human chronic myeloid leukemia cell line derived from a T-lymphocyte acute phase of CML.

Detailed Summary

CML-T1 is a human chronic myeloid leukemia (CML) cell line established from a T-lymphocyte acute phase of CML. It is characterized by the presence of the Philadelphia (Ph) chromosome and the BCR/ABL1 fusion gene, which is a hallmark of CML. The cell line exhibits features of type IV thymocytes and has a specific karyotype of 47,XX, del(11), t(6;7)(q23;q34), + mar. CML-T1 is used in research to study the molecular mechanisms of CML, including the role of the BCR/ABL1 fusion gene in leukemogenesis and the development of targeted therapies. It is also utilized for studying the genetic and molecular changes associated with CML progression and resistance to treatment.

Research Applications

Study of BCR/ABL1 fusion gene in CMLInvestigation of leukemogenesis mechanismsDevelopment of targeted therapies for CMLAnalysis of genetic and molecular changes in CML progression

Key Characteristics

Presence of Philadelphia (Ph) chromosomeBCR/ABL1 fusion geneKaryotype 47,XX, del(11), t(6;7)(q23;q34), + marFeatures of type IV thymocytes

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1126
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	36
Age Category	Adult
Sex	Female
Subtype Features	BCR-ABL1

Disease Information

Disease	Chronic myeloid leukemia
Lineage	Myeloid
Subtype	Chronic Myeloid Leukemia, BCR-ABL1+
OncoTree Code	CMLBCRABL1

DepMap Information

Source Type	DSMZ
Source ID	ACH-000920_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg290Cys (c.868C>T)	Heterozygous	-	Unknown
MutationSimple	TP53	p.Arg181Cys (c.541C>T)	Heterozygous	-	PubMed=21173094, PubMed=1373872
MutationSimple	PTEN	p.Thr321fs*23 (c.963delA)	Heterozygous	-	Unknown, Unknown
Gene fusion	ABL1	BCR-ABL1, BCR-ABL	-	BCR exon 1 fused to ABL1 exon 2	PubMed=10576511, PubMed=10071072, PubMed=8751477

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

11,12

D13S317

10,13

D16S539

10,11

D18S51

13,14

D19S433

13

D21S11

29,30

D2S1338

17,19

D3S1358

14,15,16

D5S818

9,11

D7S820

8,11

D8S1179

13,14

FGA

20,22

Penta D

12,13

Penta E

15,16,23,24

TH01

7,9

TPOX

8,11

vWA

16,20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines.

Virgili A., Nacheva E.

Mol. Cytogenet. 3:15.1-15.12(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Langerak A.W.

Leukemia 21:230-237(2007).

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";

Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.

Leuk. Res. 23:1055-1060(1999).

Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.

Drexler H.G., MacLeod R.A.F., Uphoff C.C.

Leuk. Res. 23:207-215(1999).

CML-T1: a cell line derived from T-lymphocyte acute phase of chronic myelogenous leukemia.

Whelan K., Yakir H., Ichimaru M., Sparkes R.S., Dreazen O.

Blood 74:1381-1387(1989).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).