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COLO 679Homo sapiens (Human)Cancer cell line

Also known as: Colorado 679, COLO679, COLO #679, COLO-679, COLO 697

🤖 AI SummaryBased on 10 publications

Quick Overview

Human melanoma cell line for cancer research and drug testing.

Detailed Summary

COLO 679 is a human melanoma cell line derived from a primary tumor. It is widely used in cancer research for studying melanoma biology, drug sensitivity, and therapeutic resistance. The cell line has been characterized for its genetic and molecular profiles, including mutations in BRAF and other oncogenes, making it a valuable model for investigating targeted therapies. COLO 679 is also utilized in studies related to cell proliferation, apoptosis, and metastasis. Its availability in various research settings makes it a key resource for understanding melanoma progression and developing new treatment strategies.

Research Applications

Cancer researchDrug testingMelanoma biologyTherapeutic resistanceCell proliferationApoptosis studiesMetastasis research

Key Characteristics

BRAF mutationsOncogene activationDrug sensitivity profilesGenetic instability

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1130
Species	Homo sapiens (Human)
Tissue Source	Soft tissue[UBERON:UBERON_0034929]

Donor Information

Age	47
Age Category	Adult
Sex	Female

Disease Information

Disease	Cutaneous melanoma
Lineage	Skin
Subtype	Cutaneous Melanoma
OncoTree Code	SKCM

DepMap Information

Source Type	DSMZ
Source ID	ACH-000805_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

11,12

D13S317

11,12

D16S539

12,13

D18S51

14,15

D19S433

14

D21S11

28

D2S1338

24,25

D3S1358

16,18

D5S818

11,12

D7S820

9,10

D8S1179

12,13

FGA

19,25

Penta D

7,11

Penta E

5,13

TH01

7,9

TPOX

9,12

vWA

15

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.

Cinatl J. Jr.

Cell Death Dis. 2:e243.1-e243.8(2011).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

Short tandem repeat profiling provides an international reference standard for human cell lines.

Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.

Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).

Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.

Toso R.J., Herlyn M., Bennett D.C.

Cancer Res. 55:2528-2532(1995).

The Wellcome Trust functional genomics cell bank: holdings.";

Sviderskaya E.V., Kallenberg D.M., Bennett D.C.

Pigment Cell Melanoma Res. 23:147-150(2010).