COLO 684Homo sapiens (Human)Cancer cell line

Also known as: Colorado 684, Colo684, COLO684, COLO #684, COLO-684

🤖 AI SummaryBased on 6 publications

Quick Overview

Human cancer cell line for research on tumor biology and drug development.

Detailed Summary

COLO 684 is a human cancer cell line derived from a tumor, widely used in cancer research for studying tumor biology and drug development. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been utilized in studies involving genomic profiling and drug sensitivity analysis. The cell line is characterized by its specific genetic and molecular features, which make it a valuable model for investigating cancer mechanisms and therapeutic responses. Research on COLO 684 has contributed to understanding the relationship between genetic alterations and drug efficacy, aiding in the development of targeted cancer therapies.

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1132
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age	63
Age Category	Adult
Sex	Female
Race	black_or_african_american

Disease Information

Disease	Endometrial adenocarcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	ECACC
Source ID	ACH-000864_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	PTEN	p.Arg130Ter (c.388C>T)	Homozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

D18S51

13,15

D19S433

14,15

D21S11

27,31.2

D2S1338

18,22

D3S1358

14,17

D5S818

12,13

D7S820

11,13

D8S1179

11,12

FGA

19,20,23

Penta D

11,12

Penta E

11,12

TH01

7,9.3

TPOX

7,8

vWA

14,15,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Web Resources

tcpaportal.org